<div dir="ltr"><div>Hi everyone, </div><div><br></div>Just a reminder about the talk today at 3:30. <div><br></div><div>Bryan <br><div><br><div class="gmail_extra"><br><div class="gmail_quote">On Mon, May 15, 2017 at 10:44 AM, Bryan Tripp <span dir="ltr"><<a href="mailto:bptripp@gmail.com" target="_blank">bptripp@gmail.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr"><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif"><span style="font-size:12.79px">Hi everyone, </span></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif"><span style="font-size:12.79px"><br></span></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif"><span style="font-size:12.79px">I'm forwarding this message on behalf of Travis DeWolf ... </span></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px">Special invited speaker session with Alexander Mathis, next Tuesday (May 23rd) at 3:30 in the PAS room 2464, discussing the work presented recently in Neuron (<a href="https://connect.uwaterloo.ca/owa/redir.aspx?C=PV4tOG5twQjngrMGkyuB_C1WsVGZZ016ClP3WZ6BonHQah9PoJvUCA..&URL=http%3a%2f%2fwww.cell.com%2fneuron%2fpdf%2fS0896-6273(17)30157-5.pdf" target="_blank">http://www.cell.com/neuron/<wbr>pdf/S0896-6273(17)30157-5.pdf</a>)</span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br><div style="margin:0px 0px 0px 0.8ex;padding-left:1ex;border-left:1px solid rgb(204,204,204)">Title: Somatosensory Cortex Plays an Essential Role in Forelimb Motor Adaptation in Mice<br></div><div style="margin:0px 0px 0px 0.8ex;padding-left:1ex;border-left:1px solid rgb(204,204,204)"> </div><div style="margin:0px 0px 0px 0.8ex;padding-left:1ex;border-left:1px solid rgb(204,204,204)">Abstract: Motor adaptation is fundamental for agile motor control in changing environments, such as perturbations of the body or tools we interact with. Motor adaptation is thought to depend on the ability to form a memory of a systematic perturbation, often called an internal model. However, the mechanisms underlying the formation, storage, and expression of such models remain unknown. I will present a mouse model, that we recently developed, to study forelimb adaptation to force field perturbations. We found that temporally precise photoinhibition of somatosensory cortex (S1) applied concurrently with the force field abolished the ability to update subsequent motor commands needed to reduce motor errors. This S1 photoinhibition did not impair basic motor patterns, post-perturbation completion of the action, or their performance in a reward-based learning task. Moreover, S1 photoinhibition after partial adaptation blocked further adaptation, but did not affect the expression of already-adapted motor commands. Thus, S1 is critically involved in updating the memory about the perturbation that is essential for forelimb motor adaptation.</div></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px">If you would like to attend lunch with Alexander, please contact <a href="https://connect.uwaterloo.ca/owa/redir.aspx?C=aucf-zHC3a0V4EHoflRwTO8VMRhV-N4-G1-v6GtjQcvQah9PoJvUCA..&URL=mailto%3atdewolf%40uwaterloo.ca" target="_blank">tdewolf@uwaterloo.ca</a></span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px">See you then! </span></font></div><div style="color:rgb(0,0,0);font-family:"segoe ui",helvetica,arial,sans-serif;font-size:medium"><font size="1"><span style="font-size:12.79px"><br></span></font></div></div>
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