<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=Windows-1252">
<style type="text/css" style="display:none;"> P {margin-top:0;margin-bottom:0;} </style>
</head>
<body dir="ltr">
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
Hi Everyone,</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
Just a reminder about today's seminar. Details are below.</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
Hope to see you there.</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div class="elementToProof" style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
Sue Ann</div>
<div id="appendonsend"></div>
<div class="elementToProof" style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
</div>
<div id="divRplyFwdMsg" dir="ltr"></div>
<div style="direction: ltr; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<b>Tuesday, July 23 at 3:30 p.m., DC1304</b>. </div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div class="elementToProof" style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<b>Speaker</b>: <a href="https://lethbridgebraindynamics.com/masami-tatsuno/" id="OWA384f851f-6cde-08c8-4987-772bb15acbb0" class="OWAAutoLink" title="https://lethbridgebraindynamics.com/masami-tatsuno/" data-auth="NotApplicable">
Masami Tatsuno</a> from the Department of Neuroscience at U Lethbridge.</div>
<div style="direction: ltr; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<b><br>
</b></div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<b>Title:</b> Activation of implicit memory during sleep, cell ensembles, and synaptic plasticity</div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
</div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<b>Abstract:</b></div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
Neural activity during rest plays an essential role in memory consolidation. Evidence has shown that explicit memory is reactivated during slow-wave sleep (SWS) and quiet wakefulness. However, there is relatively little evidence for the reactivation of implicit
memory. Therefore, we have investigated the neural activity of rats’ primary motor cortex while they learn an implicit memory task. Five rats were implemented with tetrode arrays, and single-unit activity was recorded when animals performed a single pellet-reaching
task. Daily recordings containing pre-task sleep, training on the reaching task, and post-task sleep continued until animals reached asymptotic performance levels. We applied PCA and found that coordinated REM and SWS activation exists and facilitates rats’
skill learning. Detection of cell ensembles using an unsupervised method also confirmed that task-associated cell ensembles were replayed during SWS and REM sleep and modulated by hippocampal sharp-wave ripples. To investigate the relationship between cell
ensembles and synaptic plasticity, we have also performed numerical simulations with spiking neural networks and two STDP rules: add-STDP and log-STDP. We found that log-STDP produced considerably more cell ensembles than add-STDP. These studies provide evidence
for the reactivation of implicit memory, cortico-hippocampal interaction during SWS, and a possible benefit of log-STDP for cell ensemble generation.</div>
<div style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
</div>
<div class="elementToProof" style="direction: ltr; text-align: left; text-indent: 0px; margin: 0px; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div style="direction: ltr; font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">
<br>
</div>
<div id="x_Signature">
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">_______________________________________________</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"><br>
</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">Dr. Sue Ann Campbell (she/her)</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">Professor and University Research Chair</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">Department of Applied Mathematics &
<a href="https://uwaterloo.ca/centre-for-theoretical-neuroscience/" id="OWAc764c047-8452-da56-b7d1-f1f2f0433054" class="x_OWAAutoLink" title="https://uwaterloo.ca/centre-for-theoretical-neuroscience/" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;">
Centre for Theoretical Neuroscience</a></span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">Associate Dean, Research, Faculty of Mathematics</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">University of Waterloo</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">Waterloo ON N2L 3G1</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"><a href="https://www.math.uwaterloo.ca/~sacampbe/" id="OWAc00f2c4c-0bfb-0d43-c40b-3ddbd9971c71" class="x_OWAAutoLink" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;">https://www.math.uwaterloo.ca/~sacampbe/</a></span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">President,
<a href="https://caims.ca/" id="OWA83b3840e-f1a9-2d83-413f-05de5987f942" class="x_OWAAutoLink" title="https://caims.ca/" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;">
Canadian Applied and Industrial Mathematics Society</a></span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"><br>
</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"><i>I acknowledge that I live and work on the traditional territory of the Chonnonton, Anishinaabeg
and Haudenosaunee peoples. The University of Waterloo main campus is located on the Haldimand tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our</i></span><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 16px; color: rgb(0, 0, 0); background-color: rgb(255, 255, 255);"><i> active
work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.</i></span></p>
<div style="direction: ltr; margin-top: 0px; margin-bottom: 0px; font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">
<br>
</div>
</div>
</body>
</html>