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</o:shapelayout></xml><![endif]--></head><body bgcolor="#D0DBE5" lang=EN-US link=blue vlink=purple style='margin-top:3.75pt'><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:#1F497D'>Hi all:</span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>For those of you who don’t subscribe to the Johns Hopkins health alerts for PCa, here is an interesting article.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen Tolhurst<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Co-facilitator PCCN Waterloo<o:p></o:p></span></p><p class=MsoNormal><img width=1 height=1 id="_x0000_i1025" src="http://www.johnshopkinshealthalerts.com/media/ui/eletterbtn.gif?ET=johnshopkins:e68015:718076i:"><o:p></o:p></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=701 style='width:525.75pt'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/eletter/profile/25/68015.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">View as a Web page</a> <o:p></o:p></span></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=1 cellspacing=4 cellpadding=0 width="50%" style='width:50.0%;background:#FFFFCC;border:outset 1.5pt'><tr><td style='padding:3.0pt 3.0pt 3.0pt 3.0pt'><p align=center style='text-align:center'><em><b><span style='font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/alerts/prostate_disorders/cryotherapy-salvage-therapy_5966-1.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">"Plan B": <br>Cryotherapy as Salvage Therapy for Prostate Cancer</a></span></b></em><span style='color:black'> <o:p></o:p></span></p><p><strong><span style='font-family:"Arial","sans-serif";color:black'>Every year, approximately a third of men with newly diagnosed prostate cancer will be treated with external beam radiation therapy or brachytherapy as their primary treatment choice. Unfortunately, many will experience a recurrence of cancer, with failure rates ranging up to 32 percent. This is when salvage cryotherapy becomes a possible option. Read more ...</span></strong><span style='color:black'><o:p></o:p></span></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=701 style='width:525.75pt;background:white'><tr><td colspan=3 style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 id="_x0000_i1026" src="http://www.johnshopkinshealthalerts.com/media/ui/prostate_disorders_banner.gif"><o:p></o:p></span></p></td></tr><tr><td colspan=3 style='background:#FFFFCC;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=right style='text-align:right;line-height:13.5pt'><b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>(800) 829-0422</span></b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> <a href="http://www.johnshopkinshealthalerts.com?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">www.johnshopkinshealthalerts.com</a> | <a href="http://www.johnshopkinshealthalerts.com/bookstore?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">Johns Hopkins Health Bookstore</a> | <a href="http://www.johnshopkinshealthalerts.com/forward/johnshopkins/68015X?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">Email this to a friend</a> <o:p></o:p></span></p></td></tr><tr><td valign=top style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p> </o:p></span></p><h1 align=center style='text-align:center'><span style='font-family:"Arial","sans-serif"'><a href="http://www.johnshopkinshealthalerts.com/alerts/prostate_disorders/cryotherapy-salvage-therapy_5966-1.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">"Plan B": Cryotherapy as Salvage Therapy for Prostate Cancer</a><o:p></o:p></span></h1><p><strong><span style='font-family:"Arial","sans-serif";color:black'>Every year, approximately a third of men with newly diagnosed prostate cancer will be treated with external beam radiation therapy or brachytherapy as their primary treatment choice. Unfortunately, many will experience a recurrence of cancer, with failure rates ranging up to 32 percent. This is when salvage cryotherapy becomes a possible option</span></strong><span style='color:black'>.<o:p></o:p></span></p><p><span style='color:black'>Think of salvage therapy for prostate cancer as "plan B," with the ultimate goal being to stop cancer growth and increase long-term survival. The time to consider it is when it's been confirmed that your initial form of cancer treatment -- external beam radiation or brachytherapy -- was not able to cure the cancer, and the disease has come back.<o:p></o:p></span></p><p><span style='color:black'>A rising PSA (prostate-specific antigen) level suggests recurrent prostate cancer, which must be confirmed by a prostate biopsy. The options available for salvage therapy of locally recurrent prostate cancer following radiation therapy include radical prostatectomy, brachytherapy, radiation therapy and cryotherapy.<o:p></o:p></span></p><p><span style='color:black'>The drawback to prostate surgery as a salvage procedure is that due to prostate scarring from the previous radiotherapy, the prostate will be very difficult to remove without significant damage to the bladder and rectum. When it comes to radiation therapy or brachytherapy as salvage possibilities, these procedures may actually cause increased rectal and urinary problems.<o:p></o:p></span></p><p><span style='color:black'>Cryotherapy is becoming an attractive option after radiation therapy failure because cryotherapy uses freezing temperatures rather than additional radiation to kill cancer cells that may somehow have become resistant to additional radiation and even to hormonal therapy.<o:p></o:p></span></p><p><strong><span style='font-family:"Arial","sans-serif";color:black'>How does cryotherapy work?</span></strong><span style='color:black'> Cryotherapy kills cancer cells by freezing them. In cryotherapy, thin needles (cryoprobes) are inserted through the perineum (the area between the scrotum and anus) and into the prostate. Needle placement is guided with an ultrasound probe placed in the rectum. Argon gas drops the temperature of the cryoprobes to a minimum of -40 degrees C (and often below -135 degrees C). The extremely low temperatures create iceballs that freeze the nearby tissue, killing the tissue and cancer cells with it. Helium is then introduced into the needles, which raises the temperature so the prostate can thaw. <o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="60%" align=center></span></div><h2 style='line-height:13.5pt'><span style='font-family:"Arial","sans-serif"'>The latest news on treating advanced prostate cancer, direct from America's #1 Medical Center<o:p></o:p></span></h2><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/advanced/advanced_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"></a></span><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><a href="http://www.johnshopkinshealthalerts.com/special_reports/advanced/advanced_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><img border=0 width=150 height=194 src="http://cdn.johnshopkinshealthalerts.com/media/ui/AdvancedCover.jpg" align=left alt="Johns Hopkins Advanced Prostate Cancer Treatments" v:shapes="_x0000_s1026"></a><![endif]><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/advanced/advanced_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"></a></span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/advanced/advanced_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments: Know Your Options When Your Cancer Comes Back</span></strong></a> features discussions with leading experts at Johns Hopkins on specific options for treating advanced prostate cancer to help you sift through all your options to decide the treatment path that is right for YOU. You will learn about current therapies as well as new approaches being developed here at Johns Hopkins and other important medical centers. These treatments include gene therapy to stop the advance of the disease, monoclonal antibodies that zap cancer cells throughout the body, angiogenesis inhibitors (drugs that choke off the blood supply to tumors) and a variety of chemotherapy agents such as Taxotere. <a href="http://www.johnshopkinshealthalerts.com/special_reports/advanced/advanced_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>Read more or order</span></strong></a><o:p></o:p></span></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellpadding=0 width="100%" style='width:100.0%'><tr style='height:.75pt'><td valign=top style='background:#164A7C;padding:.75pt .75pt .75pt .75pt;height:.75pt'><p class=MsoNormal style='mso-line-height-alt:.75pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 width=1 height=1 id="_x0000_i1028" src="http://www.johnshopkinshealthalerts.com/media/ui/spacer.gif"><o:p></o:p></span></p></td></tr><tr><td style='padding:.75pt .75pt .75pt .75pt'><p class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 id="_x0000_i1029" src="http://www.johnshopkinshealthalerts.com/images/jhbestsellers.gif"><o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/Restore_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><span style='text-decoration:none'><img border=0 id="_x0000_i1030" src="http://cdn.johnshopkinshealthalerts.com/media/ui/ProstateSexCover3D.gif"></span><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></a></span></p><p class=MsoNormal style='line-height:13.5pt'><u><span style='font-size:9.0pt;font-family:Symbol;color:blue'><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/Restore_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">·<span style='font-family:"Arial","sans-serif"'> </span></a><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/Restore_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>Restoring Sexual Intimacy After Prostate Cancer Treatment </span></strong></a></span></u><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Written by Drs. Jacek Mostwin and H. Ballentine Carter from the James Buchanan Brady Urological Institute at Johns Hopkins, <a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/Restore_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>Restoring Sexual Intimacy After Prostate Cancer Treatment </span></strong></a>presents the latest thinking on erection rehabilitation after radical prostatectomy. It explores the full range of erectile dysfunction treatment options -- effective oral medications, injection therapy, penile implants and more. The report includes answers to dozens of real questions from patients on sexuality and prostate cancer. <o:p></o:p></span></p><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/Restore_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>Read more or order</span></strong></a> <o:p></o:p></span></p></td></tr><tr style='height:.75pt'><td valign=top style='background:#164A7C;padding:.75pt .75pt .75pt .75pt;height:.75pt'><p class=MsoNormal style='mso-line-height-alt:.75pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 width=1 height=1 id="_x0000_i1031" src="http://www.johnshopkinshealthalerts.com/media/ui/spacer.gif"><o:p></o:p></span></p></td></tr></table><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="100%" align=center></span></div><p><span style='color:black'>You are receiving this email as part of your free subscription to Johns Hopkins Health Alerts. 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Click here: <a href="http://www.johnshopkinshealthalerts.com/contact_us/?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">http://www.johnshopkinshealthalerts.com/contact_us/</a><br><br>Johns Hopkins Health Alerts<br>500 Fifth Avenue<br>19th Floor<br>New York, NY 10110<br>Attn: Web Team<o:p></o:p></span></p><p><span style='color:black'>We value your privacy and will not give your email address to anyone. <a href="http://www.johnshopkinshealthalerts.com/about/privacy.html">Click here</a> to view our privacy policy.<o:p></o:p></span></p><p><span style='color:black'>This information is not intended to substitute for the advice of a physician. <a href="http://www.johnshopkinshealthalerts.com/about/disclaimer.html">Click here for additional information</a>.<br><br>Copyright © 2011 Remedy Health Media, LLC. 500 Fifth Avenue, 19th Floor, New York, NY 10110. All rights reserved.<o:p></o:p></span></p></td><td style='background:#D0DBE5;padding:3.75pt 3.75pt 3.75pt 3.75pt'></td><td width=150 valign=top style='width:112.5pt;padding:7.5pt 7.5pt 7.5pt 7.5pt'><table class=MsoNormalTable border=0 cellspacing=10 cellpadding=0 width="100%" style='width:100.0%'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=highlightalt><strong><span style='font-family:"Arial","sans-serif"'>Further Reading</span></strong><o:p></o:p></p><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/bulletins/prostate_bulletin/main_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><span style='text-decoration:none'><img border=0 id="_x0000_i1033" src="http://cdn.johnshopkinshealthalerts.com/media/ui/Bul_Pros_Ofie_Cover.gif"></span></a><o:p></o:p></span></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:Symbol;color:black'>·</span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> <a href="http://www.johnshopkinshealthalerts.com/bulletins/prostate_bulletin/main_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>The Johns Hopkins Prostate Disorders Bulletin</span></strong></a> <br>If you're interested in staying up to date on developments in prostate disorders, we recommend a subscription to <a href="http://www.johnshopkinshealthalerts.com/bulletins/prostate_bulletin/main_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>The Johns Hopkins Prostate Disorders Bulletin.</span></strong></a> This indispensable quarterly journal is written for men with prostate cancer and the other prostate health concerns: benign prostatic hyperplasia (BPH), prostatitis, lower urinary tract symptoms (LUTS), overactive bladder (OA) and erectile dysfunction (ED). Written by Dr. Jacek L. Mostwin and his esteemed colleagues at the world-renowned James Buchanan Brady Urological Institute at Johns Hopkins, <a href="http://www.johnshopkinshealthalerts.com/bulletins/prostate_bulletin/main_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><strong><span style='font-family:"Arial","sans-serif"'>The Johns Hopkins Prostate Disorders Bulletin</span></strong></a> goes beyond the basics to report on the latest therapeutic treatments and gives news of clinical trials, in-depth reports and new medications, plus detailed answers to subscribers' concerns about all aspects of prostate health. <strong><span style='font-family:"Arial","sans-serif"'><a href="http://www.johnshopkinshealthalerts.com/bulletins/prostate_bulletin/main_landing.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">Order now and receive five FREE Special Reports.</a></span></strong><o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="50%" align=center></span></div></td></tr></table><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black;display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=10 cellpadding=0 width="100%" style='width:100.0%'><tr><td width=197 style='width:147.75pt;background:#164A7C;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 width=8 height=1 id="_x0000_i1035" src="http://www.johnshopkinshealthalerts.com/media/ui/spacer.gif"><o:p></o:p></span></p></td></tr><tr><td width=197 style='width:147.75pt;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p><strong><span style='font-family:"Arial","sans-serif";color:black'>Come see what's NEW in the </span></strong><b><span style='color:black'><br><strong><span style='font-family:"Arial","sans-serif"'><a href="http://www.johnshopkinshealthalerts.com/bookstore/index.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">Bookstore</a></span></strong></span></b><span style='color:black'><o:p></o:p></span></p><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/bookstore/index.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><span style='text-decoration:none'><img border=0 width=150 height=244 id="_x0000_i1036" src="http://cdn.johnshopkinshealthalerts.com/media/ui/bookstoreAd.gif"></span></a><o:p></o:p></span></p><p style='line-height:10.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>Here you'll find Newsletters, Bulletins and White Papers in both print and instant PDF download formats, plus our latest FREE Special Reports. <a href="http://www.johnshopkinshealthalerts.com/bookstore/index.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001">Johns Hopkins Bookstore<span style='font-weight:normal'><o:p></o:p></span></a></span></strong></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p> </o:p></span></p></td></tr></table><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black;display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0><tr><td width=197 style='width:147.75pt;background:#164A7C;padding:1.5pt 1.5pt 1.5pt 1.5pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 width=10 height=1 id="_x0000_i1037" src="http://www.johnshopkinshealthalerts.com/images/spacer.gif"><o:p></o:p></span></p></td></tr><tr><td style='padding:1.5pt 1.5pt 1.5pt 1.5pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0><tr><td style='padding:1.5pt 1.5pt 1.5pt 1.5pt'><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/about/usnewsbesthospital.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><span style='text-decoration:none'><img border=0 width=95 height=110 id="_x0000_i1038" src="http://www.johnshopkinshealthalerts.com/images/best_hospitals_2007.gif" alt="Ranked Best Hospital in America 2007: Johns Hopkins"></span></a>Johns Hopkins is ranked #1 of America's Best Hospitals by <br><a href="http://www.johnshopkinshealthalerts.com/about/usnewsbesthospital.html?ET=johnshopkins:e68015:718076a:&st=email&s=EPH_111116_001"><em><b><span style='font-family:"Arial","sans-serif"'>U.S. News & World Report</span></b></em></a>. 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