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</o:shapelayout></xml><![endif]--></head><body bgcolor="#D0DBE5" lang=EN-CA link=blue vlink=purple style='margin-top:3.75pt'><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>FYI, see below.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Johns Hopkins Health Alerts [mailto:johnshopkins@e.johnshopkinshealthalerts.com] <br><b>Sent:</b> June 5, 2013 6:02 AM<br><br><b>Subject:</b> Prostate Disorders: What We Can Learn by Measuring PSA Velocity<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img width=1 height=1 id="_x0000_i1025" src="http://www.johnshopkinshealthalerts.com/media/ui/eletterbtn.gif?ET=johnshopkins:e111516:416023i:" alt="Please Enable Images"><o:p></o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=701 style='width:525.75pt'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/eletter/profile/25/111516.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">View as a Web page</a> <o:p></o:p></span></p></td></tr></table></div><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black;display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=1 cellspacing=4 cellpadding=0 width="60%" style='width:60.0%;background:#FFFFCC;border:outset 1.5pt'><tr><td style='padding:3.0pt 3.0pt 3.0pt 3.0pt'><h2 align=center style='text-align:center;line-height:13.5pt'><span style='font-family:"Arial","sans-serif"'>Understand Your Options BEFORE You Decide on Prostate Cancer Treatment<o:p></o:p></span></h2><p style='line-height:10.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"></a></span></strong><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"><img border=0 width=125 height=175 src="http://www.johnshopkinshealthalerts.com/newspics/Choosing2cover.gif" align=left v:shapes="_x0000_s1026"></a><![endif]><b><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"><strong><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></strong></a></span></b></p><p align=center style='text-align:center'><strong><span style='font-family:"Arial","sans-serif";color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">Choosing the Right Treatment for Prostate Cancer</a></span></strong><b><span style='color:black'> is a must-read primer for any man recently diagnosed with prostate cancer who is looking for answers to pressing questions about treatment options. Our specialists explain in depth: proactive surveillance, also known as expectant management ... nerve-sparing radical prostatectomy ... radiation therapy, including EBRT, 3DCRT, IMRT, IGT and brachytherapy. Written by Jacek L. Mostwin, M.D. and colleagues at the renowned James Buchanan Brady Urological Institute at Johns Hopkins -- one of the world's leading urology centers -- <a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"><strong><span style='font-family:"Arial","sans-serif"'>Choosing the Right Treatment for Prostate Cancer</span></strong></a> takes you step-by-step through the decision-making process to help you make informed choices. <strong><span style='font-family:"Arial","sans-serif"'><a href="http://www.johnshopkinshealthalerts.com/special_reports/prostate/special_report/main_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">Order today.</a><o:p></o:p></span></strong></span></b></p></td></tr></table></div><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black;display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=701 style='width:525.75pt;background:white'><tr><td colspan=3 style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 id="_x0000_i1026" src="http://cdn.johnshopkinshealthalerts.com/media/ui/prostate_disorders_banner.gif" alt="Johns Hopkins Prostate Disorders Health Alert"><o:p></o:p></span></p></td></tr><tr><td colspan=3 style='background:#FFFFCC;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=right style='text-align:right;line-height:13.5pt'><b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><a href="mailto:editor@johnshopkinshealthalerts.com">Contact Us</a></span></b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> <a href="http://www.johnshopkinshealthalerts.com?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">www.johnshopkinshealthalerts.com</a> | <a href="http://www.johnshopkinshealthalerts.com/bookstore?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">Johns Hopkins Health Bookstore</a> | <a href="http://www.johnshopkinshealthalerts.com/forward/johnshopkins/111516X?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">Email this to a friend</a> | <o:p></o:p></span></p></td></tr><tr><td valign=top style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p> </o:p></span></p><h1 align=center style='text-align:center'><span style='font-family:"Arial","sans-serif"'><a href="http://www.johnshopkinshealthalerts.com/alerts/prostate_disorders/Measuring-PSA-Velocity_6566-1.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">What We Can Learn by Measuring PSA Velocity</a><o:p></o:p></span></h1><p><strong><span style='font-family:"Arial","sans-serif";color:black'>The prostate-specific antigen (PSA) test measures an enzyme produced almost exclusively by the glandular cells of the prostate. It is secreted during ejaculation into the prostatic ducts that empty into the urethra. PSA liquefies semen after ejaculation, promoting the release of sperm. Normally, only very small amounts of PSA are present in the blood. But an abnormality of the prostate can disrupt the normal architecture of the gland and create an opening for PSA to pass into the bloodstream. Thus, high blood levels of PSA can indicate prostate problems, including cancer. PSA blood levels are expressed as nanograms per milliliter (ng/mL). </span></strong><span style='color:black'><o:p></o:p></span></p><p><strong><span style='font-family:"Arial","sans-serif";color:black'>PSA velocity</span></strong><span style='color:black'> is a measurement of annual changes in PSA values, which rise more rapidly in men with prostate cancer than in men without the disease. A study from Johns Hopkins and the National Institute on Aging found that an increase in PSA level of more than 0.75 ng/mL per year was an early predictor of prostate cancer in men with PSA levels between 4 ng/mL and 10 ng/mL.<o:p></o:p></span></p><p><span style='color:black'>PSA velocity is especially helpful in detecting early cancer in men with mildly elevated PSA levels and a normal digital rectal exam. It is most useful in predicting the presence of cancer when changes in PSA are evaluated over at least one to two years. In a study reported in <em><span style='font-family:"Arial","sans-serif"'>The New England Journal of Medicine</span></em>, a rapid rise in PSA level (more than 2 ng/mL) in the year before prostate cancer diagnosis and surgical treatment predicted a higher likelihood that a man would die of his prostate cancer over the next seven years.<o:p></o:p></span></p><p><span style='color:black'>Moreover, a Johns Hopkins study published in the <em><span style='font-family:"Arial","sans-serif"'>Journal of the National Cancer Institute</span></em> found that a man's PSA velocity 10 to 15 years before he was diagnosed with prostate cancer predicted his survival from the disease 25 years later. In the study, 92 percent of men with an earlier PSA velocity of 0.35 ng/mL or less per year had survived, compared with 54 percent of men whose PSA velocity was greater than 0.35 ng/mL.<o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="60%" align=center></span></div><p><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"></a></span><!--[if gte vml 1]><v:shape id="_x0000_s1027" type="#_x0000_t75" alt="Managing Urinary Incontinence After Prostate Cancer Surgery Cover Image" href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001" style='position:absolute;margin-left:0;margin-top:0;width:112.5pt;height:150pt;z-index:251659264;mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0;mso-wrap-distance-bottom:0;mso-position-horizontal:left;mso-position-horizontal-relative:text;mso-position-vertical-relative:line' o:allowoverlap="f" o:button="t">
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</v:shape><![endif]--><![if !vml]><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"><img border=0 width=150 height=200 src="http://cdn.johnshopkinshealthalerts.com/media/ui/ProstUrinaryIncontinence_Cover.jpg" align=left alt="Managing Urinary Incontinence After Prostate Cancer Surgery Cover Image" v:shapes="_x0000_s1027"></a><![endif]><span style='color:black'><a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"></a></span><span style='color:black'><o:p></o:p></span></p><h2 style='line-height:13.5pt'><span style='font-family:"Arial","sans-serif"'>The OTHER side effect of radical prostatectomy<o:p></o:p></span></h2><p><span style='color:black'>Many men undergoing a radical prostatectomy for prostate cancer focus on erectile dysfunction as the major complication they face. But in fact, following prostate surgery, men often confront another potentially more troubling complication: urinary incontinence. By some estimates, 50 to 60 percent of all men suffer from serious incontinence after surgery for prostate cancer. Whether you are already experiencing incontinence symptoms -- or you are a candidate for prostate cancer surgery and would like to take steps to reduce the risk of incontinence -- <a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001"><strong><span style='font-family:"Arial","sans-serif"'>Managing Urinary Incontinence After Prostate Cancer Surgery</span></strong></a> can help. You'll read about nonsurgical therapies for chronic mild to moderate urinary incontinence, as well as medications and medical treatments. The report also presents a multistep bladder retraining program that offers effective strategies for treating incontinence. <strong><span style='font-family:"Arial","sans-serif"'>Available now for just $19.95 with a FULL Money-Back Guarantee of Satisfaction. <a href="http://www.johnshopkinshealthalerts.com/special_reports/Prostate_reports/pros_incon_digital_landing.html?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">Read more or order.</a><o:p></o:p></span></strong></span></p><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="100%" align=center></span></div><p><span style='color:black'>You are receiving this email as part of your free subscription to Johns Hopkins Health Alerts. Should you wish to unsubscribe, please follow the instructions below. Help us be sure this email Health Alert isn't filtered as spam. 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Click here: <a href="http://www.johnshopkinshealthalerts.com/contact_us/?ET=johnshopkins:e111516:416023a:&st=email&s=EPH_130605_001">http://www.johnshopkinshealthalerts.com/contact_us/</a><br><br>Johns Hopkins Health Alerts<br>500 Fifth Avenue<br>19th Floor<br>New York, NY 10110<br>Attn: Web Team<o:p></o:p></span></p><p><span style='color:black'>We value your privacy and will not give your email address to anyone. <a href="http://www.johnshopkinshealthalerts.com/about/privacy.html">Click here</a> to view our privacy policy.<o:p></o:p></span></p><p><span style='color:black'>This information is not intended to substitute for the advice of a physician. <a href="http://www.johnshopkinshealthalerts.com/about/disclaimer.html">Click here for additional information</a>.<br><br>Copyright © 2013 Remedy Health Media, LLC. 500 Fifth Avenue, 19th Floor, New York, NY 10110. 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