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</o:shapelayout></xml><![endif]--></head><body lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Interesting article that reinforces the need to consider family history as it relates to Prostate Cancer.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Ensure family members of those diagnosed with PCa get a PSA test.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Thx.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><br><b>Subject:</b> FYI From urotoday.com Topic: Impact of family history on prostate cancer mortality in Caucasian men undergoing PSA-based screening<o:p></o:p></span></p></div><p class=MsoNormal><o:p> </o:p></p><div><div><h1><a href="http://www.urotoday.com/Prostate-Cancer/impact-of-family-history-on-prostate-cancer-mortality-in-caucasian-men-undergoing-psa-based-screening-abstract.html">Impact of family history on prostate cancer mortality in Caucasian men undergoing PSA-based screening - Abstract</a> <o:p></o:p></h1><div><div><div><div><p class=MsoNormal>Published on 04 September 2014<o:p></o:p></p><p><strong>PURPOSE:</strong> To assess if prostate cancer (PCa) screening reduces PCa mortality in Caucasian men with a family history (FH) of prostate cancer.<o:p></o:p></p><p><strong>MATERIALS AND METHODS:</strong> Data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial was used to compare screening and usual care arms within the subset of men with and without a FH of PCa. Univariate, multivariate cox regression analysis, and log-rank analysis of Kaplan-Meier curves were used to examine the data for differences in PCa specific survival.<o:p></o:p></p><p><strong>RESULTS:</strong> A total of 65,179 Caucasian subjects were included in the PSA screening trial, of which 7314 (11.2%) were diagnosed with PCa. Only 4,833 (7.4%) of Caucasian men had a FH of PCa. FH+ men had a significantly higher PCa incidence (16.9% vs. 10.8%; p< 0.01) and higher PCa specific mortality (0.56% vs. 0.37%; P< 0.01), which trended to significance in multivariate analysis (HR 1.47, 95% CI: 0.98-2.21; p=0.06). Screening FH+ men also showed a trend towards decreased PCa specific mortality with a hazard ratio of 0.49 (95% CI 0.22-1.1; p=0.08) and also a reduced time to death from PCa (log-rank; p=0.05).<o:p></o:p></p><p><strong>CONCLUSIONS:</strong> Caucasian men with a FH of PCa are at increased risk of being diagnosed and subsequently dying from prostate cancer. Yearly digital rectal exams and PSA testing may reduce prostate cancer death in these individuals.<o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'><strong>Written by:</strong> <br>Liss MA, Chen H, Hemal S, Krane S, Kane CJ, Xu J, Kader AK. <a href="http://www.urotoday.com/index.php?option=com_content&Itemid=797&catid=1168&id=18027&lang=en&view=article"><span style='font-size:7.5pt'> Are you the author?</span></a> <br><em>UC San Diego Health System, Department of Urology, San Diego, CA; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Wake Forest University School of Medicine, Departments of Genomics and Personalized Medicine Research, Winston-Salem, NC; Department of Urology Wake Forest University School of Medicine; UC San Diego Health System, Department of Urology, San Diego, CA. <a href="mailto:mliss008@gmail.com">mliss008@gmail.com</a></em><i><br><br></i><o:p></o:p></p></div><div><p class=MsoNormal><em>url:<a href="http://www.urotoday.com/Prostate-Cancer/impact-of-family-history-on-prostate-cancer-mortality-in-caucasian-men-undergoing-psa-based-screening-abstract.html">http://www.urotoday.com/Prostate-Cancer/impact-of-family-history-on-prostate-cancer-mortality-in-caucasian-men-undergoing-psa-based-screening-abstract.html</a></em><o:p></o:p></p></div></div></div></div></div></div></div></body></html>