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</o:shapelayout></xml><![endif]--></head><body lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Interesting article.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><br><b>Sent:</b> April 2, 2015 12:49 PM<br><br><b>Subject:</b> FYI From dailymail.co.uk Topic: Prostate cancer breakthrough as scientists discover WHY the disease spreads, paving way for better treatments<o:p></o:p></span></p></div><p class=MsoNormal><o:p> </o:p></p><div><h1>Prostate cancer breakthrough as scientists discover WHY the disease spreads, paving way for better treatments<o:p></o:p></h1><ul type=disc><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1'><strong><span style='font-size:17.0pt'>British scientists say they have got to the 'root' of prostate cancer</span></strong><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1'><strong><span style='font-size:17.0pt'>Have exposed an Achilles' heel that could lead to better survival chances </span></strong><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1'><strong><span style='font-size:17.0pt'>Could mean that men get </span></strong><strong><span style='font-size:13.0pt'>individualised</span></strong><strong><span style='font-size:17.0pt'> treatments within a few years </span></strong><o:p></o:p></li></ul><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>By <a href="http://www.dailymail.co.uk/home/search.html?s=&authornamef=Fiona+Macrae,+Daily+Mail+Science+Correspondent">Fiona Macrae, Daily Mail Science Correspondent</a> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>Published: 12:09 EST, 1 April 2015 | Updated: 19:47 EST, 1 April 2015 <o:p></o:p></p><div><p class=MsoNormal><span style='color:black'><br> </span><span style='font-size:14.5pt;color:#222222'>British scientists have discovered an ‘Achilles’ heel’ in prostate cancer which could lead to better treatments.</span><span style='color:black'><o:p></o:p></span></p></div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>The disease claims almost 11,000 lives a year in the UK, with most deaths occurring after it spreads around the body.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>The latest study gets to the root of this spread, and could mean better outcomes for the 42,000 men a year diagnosed with the illness.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>Scientists funded by Cancer Research UK studied samples taken from tumours in the prostate and around the body in ten affected men.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>Reading the DNA revealed details of how the cancer metastasises, or spreads, allowing them to build a ‘family tree’ of how the disease changes over time.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>It seems that most of the cells in a tumour stay where they are. However, a small number have the ability to travel through the body, creating new tumours as they go.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>These cells are the ‘root’ of the cancer and for a treatment to work, they should be destroyed.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>In future, doctors may be able to find these key cells in individual patients. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>They could then be given drugs to wipe them out, with each patient’s treatment tailored to the genetic flaw at the root of their cancer. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>This should kill the new tumours and prevent more from forming, greatly improving odds of survival.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>Cambridge University researcher Professor David Neal said some suitable drugs already exist, and that new ones are being developed all the time. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>However, he cautioned that it will be three to five years before the latest knowledge can be routinely put to use in the NHS.</span><o:p></o:p></p><div><div id=p-16><div><div><h2><span style='font-size:13.5pt;font-weight:normal'>Lead study author Professor Ros Eeles, from the Institute of Cancer Research in London, said: ‘We gained a much broader view of prostate cancer by studying both the original cancer and the cells that had spread to other parts of the body.</span><o:p></o:p></h2></div></div></div></div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>‘We found that all of the cells that had broken free shared a common ancestor cell in the prostate.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>‘The common faults we found in each man could potentially offer new targets for treatment.’</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>Co-author Dr Ultan McDermott, from the Wellcome Trust Sanger Institute in Cambridgeshire, described the finding as a ‘potential Achilles’ heel’.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:14.5pt'>Professor Peter Johnson, chief clinician at Cancer Research UK, said: ‘This research lets us look right into the molecular core of cancer.’ </span><o:p></o:p></p><div><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:black'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='color:black'>url: <a href="http://www.dailymail.co.uk/health/article-3021800/Prostate-cancer-breakthrough-scientists-discover-disease-spreads-paving-way-better-treatments.html#ixzz3WAg6BVSR"><span style='color:#003399'>http://www.dailymail.co.uk/health/article-3021800/Prostate-cancer-breakthrough-scientists-discover-disease-spreads-paving-way-better-treatments.html#ixzz3WAg6BVSR</span></a> <br> <o:p></o:p></span></p></div></div></div></body></html>