<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=utf-8"><meta name=Generator content="Microsoft Word 12 (filtered medium)"><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
h2
{mso-style-priority:9;
mso-style-link:"Heading 2 Char";
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:18.0pt;
font-family:"Times New Roman","serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
span.Heading2Char
{mso-style-name:"Heading 2 Char";
mso-style-priority:9;
mso-style-link:"Heading 2";
font-family:"Cambria","serif";
color:#4F81BD;
font-weight:bold;}
p.node, li.node, div.node
{mso-style-name:node;
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.EmailStyle19
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Interesting article.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>The 2<sup>nd</sup> last line shows enlightenment.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><br><b>Subject:</b> FYI From webmd.com Topic:Adding chemotherapy to hormone therapy added 14 months to patients' lives in study<o:p></o:p></span></p></div><p class=MsoNormal><o:p> </o:p></p><div><div id=textArea><h2>This May Boost Advanced Prostate Cancer Survival<o:p></o:p></h2><div><p class=MsoNormal>Adding chemotherapy to hormone therapy added 14 months to patients' lives in study<o:p></o:p></p></div><div><p class=MsoNormal><br>WebMD News from HealthDay<o:p></o:p></p></div><p class=node>By Steven Reinberg<o:p></o:p></p><p class=node><i>HealthDay Reporter</i> <o:p></o:p></p><p class=node>WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- <a href="http://www.webmd.com/cancer/chemotherapy-what-to-expect">Chemotherapy</a> at the start of hormone therapy can extend the lives of men with <a href="http://www.webmd.com/prostate-cancer/default.htm">prostate cancer</a> that has spread beyond the gland, a new study finds.<o:p></o:p></p><p class=node>Over nearly 29 months of follow-up, men with advanced <a href="http://www.webmd.com/prostate-cancer/ss/slideshow-prostate-cancer-overview">prostate cancer</a> who received the combination therapy lived almost 14 months longer than men who received only hormone therapy (58 months versus 44 months), researchers said.<o:p></o:p></p><p class=node>"Men who have hormone-sensitive <a href="http://www.webmd.com/prostate-cancer/metastatic-prostate-15/metastatic-prostate-cancer">metastatic prostate cancer</a> should speak with their doctors about having this combination treatment to significantly prolong their survival," said lead researcher Dr. Christopher Sweeney, an associate professor of medicine at Harvard Medical School.<o:p></o:p></p><p class=node>For 50 years, hormone therapy has been the standard care for these patients, he said. Adding <a href="http://www.webmd.com/cancer/facing-chemotherapy-15/getting-ready/video-starting-chemo">chemotherapy</a> to hormone therapy is worth doing because even though it's not a cure, it does improve survival and quality of life, Sweeney said.<o:p></o:p></p><p class=node>The study was funded by the U.S. National <a href="http://www.webmd.com/cancer/">Cancer</a> Institute, and the report was published Aug. 5 online in the <i>New England Journal of Medicine</i>.<o:p></o:p></p><p class=node>For the study, Sweeney and colleagues randomly assigned 790 men with prostate cancer, average age 63, to chemotherapy plus hormone therapy or hormone therapy alone.<o:p></o:p></p><p class=node>In addition to the survival benefit, men who received the combination of chemotherapy and hormone therapy saw their cancer remain dormant for more than 20 months before it began to progress, compared with close to 12 months among those who only received hormone therapy, researchers found.<o:p></o:p></p><p class=node>Sweeney said that side effects of the chemotherapy were mild, in general. Fatigue, low <a href="http://www.webmd.com/a-to-z-guides/complete-blood-count-cbc">white blood cell count</a> and infection were the most common side effects, the study said. One man died from an unknown cause, though researchers said the death may have been due to the chemotherapy. The man probably should not have been in the trial in the first place, Sweeney said.<o:p></o:p></p><p class=node>One of the criteria for the treatment is that patients should be able to handle the chemotherapy, Sweeney said. If they have other conditions such as <a href="http://www.webmd.com/hepatitis/rmq-know-your-liver">liver</a> or <a href="http://www.webmd.com/a-to-z-guides/understanding-kidney-disease-basic-information">kidney disease</a>, they should not be getting chemotherapy, he said.<o:p></o:p></p><p class=node>Dr. Anthony D'Amico, chief of <a href="http://www.webmd.com/cancer/what-to-expect-from-radiation-therapy">radiation</a> oncology at Brigham and Women's Hospital in Boston, said, "This is an important study that will change practice."<o:p></o:p></p><p class=node>In the study, the greatest benefit was seen in men who had four or more tumors outside the prostate, but D'Amico, who wasn't involved with the research, believes chemotherapy will also help men with fewer tumors. "It will probably work across the board," he said.<o:p></o:p></p><p class=node>Other studies, D'Amico said, have confirmed these findings. "<span style='background:yellow;mso-highlight:yellow'>This drives home the point that we should change practice,"</span> he said.<o:p></o:p></p><p class=node>"It's not curing prostate cancer," he said. "But it's certainly increasing the time people have."<o:p></o:p></p><p class=node><o:p> </o:p></p><p class=node><o:p> </o:p></p><p class=node><o:p> </o:p></p><p class=node><o:p> </o:p></p><p class=node>url:<a href="http://www.webmd.com/prostate-cancer/news/20150805/combo-treatment-may-boost-survival-with-advanced-prostate-cancer">http://www.webmd.com/prostate-cancer/news/20150805/combo-treatment-may-boost-survival-with-advanced-prostate-cancer</a><o:p></o:p></p></div></div></div></body></html>