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</o:shapelayout></xml><![endif]--></head><body lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Interesting article based on Canadian information.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><br><b>Subject:</b> FYI From urotoday.com Topic: Active surveillance for the management of localized prostate cancer: Gu<o:p></o:p></span></p></div><p class=MsoNormal><o:p> </o:p></p><div><h2>Active surveillance for the management of localized prostate cancer: Guideline recommendations. <o:p></o:p></h2><p>Published: 07 August 2015 <o:p></o:p></p><p>INTRODUCTION - The objective is to provide guidance on the role of active surveillance (AS) as a management strategy for low-risk prostate cancer patients and to ensure that AS is offered to appropriate patients assessed by a standardized protocol. Prostate cancer is often a slowly progressive or sometimes non-progressive indolent disease diagnosed at an early stage with localized tumours that are unlikely to cause morbidity or death.<o:p></o:p></p><p>Standard active treatments for prostate cancer include radiotherapy (RT) or radical prostatectomy (RP), but the harms from over diagnosis and overtreatment are of a significant concern. AS is increasingly being considered as a management strategy to avoid or delay the potential harms caused by unnecessary radical treatment.<o:p></o:p></p><p>METHODS - A literature search of MEDLINE, EMBASE, the Cochrane library, guideline databases and relevant meeting proceedings was performed and a systematic review of identified evidence was synthesized to make recommendations relating to the role of AS in the management of localized prostate cancer.<o:p></o:p></p><p>RESULTS - No exiting guidelines or reviews were suitable for use in the synthesis of evidence for the recommendations, but 59 reports of primary studies were identified. Due to studies being either non-comparative or heterogeneous, pooled meta-analyses were not conducted.<o:p></o:p></p><p>CONCLUSIONS - The working group concluded that for patients with low-risk (Gleason score ≤6) localized prostate cancer, AS is the preferred disease management strategy. Active treatment (RP or RT) is appropriate for patients with intermediate-risk (Gleason score 7) localized prostate cancer. For select patients with low-volume Gleason 3+4=7 localized prostate cancer, AS can be considered.<o:p></o:p></p><p>Can Urol Assoc J. 2015 May-Jun;9(5-6):171-8. doi: 10.5489/cuaj.2806.<o:p></o:p></p><p>Morash C1, Tey R2, Agbassi C2, Klotz L3, McGowan T4, Srigley J5, Evans A6.<o:p></o:p></p><p>1 Division of Urology, University of Ottawa, Ottawa, ON;<br>2 Program in Evidence-based Care, Cancer Care Ontario, McMaster University, Hamilton, ON;<br>3 Division of Urology, Sunnybrook Health Sciences Centre, Toronto, ON;<br>4 The Cancer Centre Bahamas & The Cancer Centre Eastern Caribbean;<br>5 Credit Valley Hospital, Mississauga, ON;<br>6 Department of Pathology and Laboratory, Faculty of Medicine, University of Toronto, Toronto, ON.<o:p></o:p></p><p><o:p> </o:p></p><p><o:p> </o:p></p><p><o:p> </o:p></p><p><o:p> </o:p></p><p class=MsoNormal>url:<a href="http://www.urotoday.com/index.php?option=com_content&view=article&id=82508:active-surveillance-for-the-management-of-localized-prostate-cancer-guideline-recommendations&catid=1134:prostate-cancer&Itemid=782&utm_source=newsletter_2882&utm_medium=email&utm_campaign=uroalerts-prostate-cancer-daily" target="_blank">http://www.urotoday.com/index.php?option=com_content&view=article&id=82508:active-surveillance-for-the-management-of-localized-prostate-cancer-guideline-recommendations&catid=1134:prostate-cancer&Itemid=782&utm_source=newsletter_2882&utm_medium=email&utm_campaign=uroalerts-prostate-cancer-daily</a><o:p></o:p></p></div><p class=MsoNormal>-- <br>You received this message because you are subscribed to the Google Groups "FYI Prostate Info" group.<br>To unsubscribe from this group and stop receiving emails from it, send an email to <a href="mailto:fyi-prostate-info+unsubscribe@googlegroups.com">fyi-prostate-info+unsubscribe@googlegroups.com</a>.<br>To post to this group, send email to <a href="mailto:fyi-prostate-info@googlegroups.com">fyi-prostate-info@googlegroups.com</a>.<br>To view this discussion on the web visit <a href="https://groups.google.com/d/msgid/fyi-prostate-info/40085613-12d0-40a2-b5a3-23e357f80b08%40googlegroups.com?utm_medium=email&utm_source=footer">https://groups.google.com/d/msgid/fyi-prostate-info/40085613-12d0-40a2-b5a3-23e357f80b08%40googlegroups.com</a>.<br>For more options, visit <a href="https://groups.google.com/d/optout">https://groups.google.com/d/optout</a>.<o:p></o:p></p></div></body></html>