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</o:shapelayout></xml><![endif]--></head><body bgcolor="#E6E6E6" lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>See below wrt ordering a relevant report.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div><div><div><p class=MsoNormal style='line-height:13.5pt'><span style='font-family:"Calibri","sans-serif";color:black'> <o:p></o:p></span></p></div></div><div><div><p class=MsoNormal style='mso-line-height-alt:13.5pt'><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:blue'> <o:p></o:p></span></p></div></div><div><p class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:black'>If you are unable to see the message below, <a href="http://links.remedyhealthmedia.mkt6207.com/servlet/MailView?ms=ODI4NzYxMQS2&r=NDk5ODA3MTk3ODIS1&j=ODAyMzg3ODYwS0&mt=1&rt=0">click here to view</a>.</span><span style='font-family:"Calibri","sans-serif";color:black'><o:p></o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=700 style='width:525.0pt;background:white'><tr><td colspan=3 style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 width=706 height=119 id="_x0000_i1025" src="http://www.healthafter50.com/media/email_images/HA50_SACH-WebBanner_706x119_Temp_Promo_F2.jpg" alt="Health After 50 Alerts"><o:p></o:p></span></p></td></tr><tr><td colspan=3 style='padding:0cm 0cm 0cm 0cm'><p align=right style='mso-margin-top-alt:0cm;margin-right:3.75pt;margin-bottom:0cm;margin-left:3.75pt;margin-bottom:.0001pt;text-align:right;line-height:13.5pt;float:right'><a name="Contact_Us_Email"></a><a href="mailto:customerservice@healthafter50.com" target="_blank"><b><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Contact Us</span></b></a><b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></b></p></td></tr><tr><td valign=top style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=center align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Special Offer from Health After 50 Alerts with Scientific American Consumer Health<o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="50%" align=center></span></div><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> : <o:p></o:p></span></p><p align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-size:13.5pt;font-family:"Arial","sans-serif";color:red'>Treatments to Control Prostate Cancer and Improve Quality of Life</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>The Must-Have "Bible" for Men with Advanced Prostate Cancer! </span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p class=MsoNormal style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> <o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><img border=0 id="_x0000_i1027" src="http://www.healthafter50.com/media/ui/SA_Prostate_Advanced_v1.jpg" alt="Scientific American Heart Attack Prevention White Paper"><o:p></o:p></span></p><p align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-size:13.5pt;font-family:"Arial","sans-serif";color:navy'>Advanced Prostate Cancer Treatments:</span></strong><b><span style='font-size:13.5pt;font-family:"Arial","sans-serif";color:navy'><br><strong><span style='font-family:"Arial","sans-serif"'>Know Your Options When Your Cancer Comes Back</span></strong></span></b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>Learn about the latest drugs and therapies for controlling the spread of prostate cancer, managing your prostate cancer symptoms and improving your quality of life.</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>* * * * * * * * * * * * * * * * * * * * * * * * *<o:p></o:p></span></p><p style='line-height:13.5pt'><em><b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:navy'>Did you know that the landscape for treating advanced prostate cancer has changed dramatically?</span></b></em><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>In just the past year there has been a <strong><span style='font-family:"Arial","sans-serif"'>paradigm shift</span></strong> in the treatment of advanced prostate cancer, due in part to results from the 2014 CHAARTED (ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer) study. CHAARTED reported that the addition of docetaxel (Taxotare) at the beginning of hormonal therapy improved survival significantly in men with advanced prostate cancer -- a survival benefit of 49.2 months compared to the 32.2-month benefit from men who only were given androgen suppression therapy.<o:p></o:p></span></p><p style='line-height:13.5pt'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>This exciting discovery offers great reason for hope for men who have advanced disease.</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><em><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Now you can read about CHAARTED and other groundbreaking therapies</span></em><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> in <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments: Know Your Options When Your Cancer Comes Back</span></strong> written by a team of top prostate cancer specialists, including <strong><span style='font-family:"Arial","sans-serif"'>Dr. Emmanuel S. Antonarakis</span></strong>, <strong><span style='font-family:"Arial","sans-serif"'>Dr. H. Ballentine Carter</span></strong>, <strong><span style='font-family:"Arial","sans-serif"'>Dr. Theodore L. DeWeese</span></strong> and <strong><span style='font-family:"Arial","sans-serif"'>Dr. Danny Song</span></strong>.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>The Challenge When Prostate Cancer Recurs</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>The work to find a cure for prostate cancer is worldwide and ongoing. And the good news is that death rates for prostate cancer have been steadily declining, thanks to early detection and improved therapies.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Still, too many men are told every day that their cancer has recurred and that they now have advanced prostate cancer.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Receiving the news that prostate cancer has returned, often after years of undetectable or steady PSA results, is shocking and bewildering to most men. When prostate cancer recurs, it immediately raises numerous concerns and important questions. <em><span style='font-family:"Arial","sans-serif"'>Is life all downhill from here? How will the cancer impact my future? What is the best therapy? How do I make the final treatment choice? Should I consider joining a clinical trial? How can I regain control of my life?</span></em><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>If you're in this group, you and your doctor must decide together on the best course of treatment.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>To help you make the difficult treatment decisions that lie ahead, you can now turn to <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments: Know Your Options When Your Cancer Comes Back</span></strong>. The contributors to this Special Health Report highlight the key issues you will be facing -- <em><span style='font-family:"Arial","sans-serif"'>and what to consider at each step of the way</span></em>.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>* * * * * * * * * * * * * * * * * * * * * * * * *<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>In <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong>, lead author Emmanuel S. Antonarakis, M.D., reviews the therapies currently being used to stop the advance of prostate cancer, and gives you the latest news on the most promising new drugs and treatments.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Dr. Antonarakis is ideally positioned to bring you the latest information about research in the fight against prostate cancer. An Assistant Professor of Oncology at the Kimmel Cancer Center at Johns Hopkins, Dr. Antonarakis focuses on testing investigational drugs in the treatment of prostate cancer, as well as new biomarkers for advanced prostate cancer. His new blood-based biomarker called <strong><span style='font-family:"Arial","sans-serif"'>androgen-receptor splice variant-7 (AR-V7)</span></strong> has caused great excitement in the field -- and is discussed in depth in <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong>.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>Designing a Personal Plan of Attack for Each Patient</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>As we have come to better understand the biologic and molecular mechanisms that fuel prostate cancer growth, new-targeted therapies have recently been approved for use. Taxotere, approved by the FDA in 2004, was for a time the only therapy available for improving survival in patients with castration-resistant prostate cancer-that is, cancer that is no longer responding to hormone therapy. But in 2012 the FDA approved enzalutamide (Xtandi) and in 2013, Xofigo. Add this to four other drugs - Provenge, Jevtana, Zytiga and recently Xgeva (a monoclonal antibody is designed to help prevent excessive breakdown of bone) -- and for the first time we have multiple treatment options to delay cancer progression.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>We also have more than 30 new drugs that are in early Phase I and II clinical trials, with eight drugs that have made it to final Phase III trials.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>With several drugs to choose from for the treatment of metastatic castration-resistant prostate cancer after chemotherapy has failed, how do doctor and patient decide <strong><span style='font-family:"Arial","sans-serif"'>which drugs to use and in which order?</span></strong><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>This is the key question doctors are currently grappling with in the advanced prostate cancer field. If doctors can come up with a predictive biomarker (the new term is 'treatment-selection biomarker'), we will have a marker that helps determine what treatment the patient should--or should not--receive next.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>In <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong> you'll read that Dr. Antonarkakis and colleagues have discovered just such a biomarker called <strong><span style='font-family:"Arial","sans-serif"'>androgen-receptor splice variant-7 (AR-V7)</span></strong>, which could help predict resistance to enzalutamide and also to abiraterone (Zytiga), the other new drug for advanced prostate cancer that targets testosterone production from the adrenal glands.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>You'll also learn about two promising new drugs in the pipeline:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l5 level1 lfo1'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Galeterone</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> -- This drug is a highly selective, multi-targeted, oral therapy for the treatment of advanced cancer that works to disrupt androgen receptor signaling, which is the key driver of prostate cancer growth. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l5 level1 lfo1'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>EPI-506</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> -- EPI-506 targets the N-terminal, the part that is thought to be critical for the androgen receptor to function. Thus far lab results have been impressive and human trials are expected to begin in mid 2015. <o:p></o:p></span></li></ul><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>You'll quickly find that <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong> is your direct line to the most current, reliable information on prostate cancer treatment options - so you can make the best-informed decisions possible about your future. <strong><span style='font-family:"Arial","sans-serif"'>This is vital, life-changing information you won't find in any other single source</span></strong>.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>Treatments to Control the Cancer, Reduce Symptoms</span></strong><b><span style='font-family:"Arial","sans-serif";color:black'><br><strong><span style='font-family:"Arial","sans-serif"'>Improve Quality of Life</span></strong></span></b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Ultimately, your decision about your prostate cancer treatment has to be guided by the clinical stage of your cancer, the extent of the disease, your age and overall health. In <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong>, you'll learn the answers to key questions such as:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Why is repeated PSA testing so crucial? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What if I have bone metastasis? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When should I consider hormone therapy to treat my recurrent prostate cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What are the side effects of hormone therapy? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What studies are available on the success of hormone therapy? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What about radiation therapy to treat my prostate cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When should I consider chemotherapy? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What new chemotherapy drugs are now available to help treat prostate cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What other studies are currently being pursued at Johns Hopkins on chemotherapy? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l3 level1 lfo2'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Where can I go for more help, support and information as I sift through my prostate cancer treatment options? <o:p></o:p></span></li></ul><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>If you're reading this letter now, you or a loved one probably has advanced prostate cancer. You want to know: <strong><span style='font-family:"Arial","sans-serif"'>What is hormone therapy, how does it work and why does it sometimes fail to slow the progress of prostate cancer?</span></strong><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>The answers to these and other questions are supplied by Dr. Antonarakis, an expert in the clinical management of patients with advanced prostate cancer. You'll learn:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The difference between surgical and medical castration to eliminate male sex hormones -- and why it's important <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The role of LHRH agonists <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Why doctors sometimes use antiandrogens <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When hormonal therapy should be started <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The side effects of hormonal therapy <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What can be done to maintain sexual function while on hormonal therapy <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l1 level1 lfo3'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How to live with hot flashes, insulin resistance, breast enlargement, weight gain and other side effects <o:p></o:p></span></li></ul><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>In <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong>, Dr. Antonarakis answers dozens of specific questions about castration-resistant prostate cancer, the same questions that may be on your mind as you tackle this complex disease:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Can you predict who's going to develop castration-resistant cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What do you mean when you say that prostate cancer is heterogeneous? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How long do you expect LHRH therapy or orchiectomy to keep prostate cancer at bay? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What second-line antiandrogen therapies are available? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Is doing nothing an option if your PSA is rising? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How does chemotherapy fight prostate cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Which do you recommend and why: Taxotere or Jevtana? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Why is prednisone used with Taxotere? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When is the best time to begin Taxotere therapy? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How do you know that Taxotere is working? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When do you recommend Provenge for castration-resistant patients? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How is Provenge made? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Since Provenge doesn't lower PSA levels, how do you know it's working? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What are the benefits of Zytiga for men with castration-resistant prostate cancer? <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l4 level1 lfo4'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What is a comprehensive cancer center? <o:p></o:p></span></li></ul><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>New Therapies That Can Change the Course of Treatment</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>In the chapter <strong><span style='font-family:"Arial","sans-serif"'>Radiation Therapy Following Prostate Cancer Surgery</span></strong> by Dr. H. Ballentine Carter, you will learn:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The clinical definition of PSA failure after radical prostatectomy <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Your options if you have a clinical relapse <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>What is definition of salvage radiation therapy <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The three potential scenarios in which radiotherapy may be beneficial <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Why a selective approach to giving radiotherapy may be best <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The four factors which are the best indicators of success for radiation therapy due to their suggesting local-only prostate cancer recurrence <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Other key factors which help predict PSA remission <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l0 level1 lfo5'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Guidelines for salvage radiation therapy to be initiated <o:p></o:p></span></li></ul><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>You will also read about <strong><span style='font-family:"Arial","sans-serif"'>Treating Prostate Cancer After Brachytherapy Failure</span></strong>, by Theodore L. DeWeese, M.D., Professor of Radiation Oncology and Urology and Chairman of the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Dr. DeWeese and his colleague, Danny Song, M.D., guide you through your questions as to how brachytherapy is supposed to work, why it is possible that it may have failed, and what your options are if that proves to be the case. When should hormone therapy be initiated? Are you still a candidate for a radical prostatectomy? What if the cancer has spread to the bone (metastasized)? How can a TURP (transurethral resection of the prostate) for BPH (enlarged prostate) affect the outcome of brachytherapy?<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>There's more to <strong><span style='font-family:"Arial","sans-serif"'>Advanced Prostate Cancer Treatments</span></strong>, much more. Key chapters in this 102-page Special Health Report include:<o:p></o:p></span></p><ul type=disc><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>When Prostate Cancer Recurs</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by H. Ballentine Carter, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Hormonal Therapy for Advanced Prostate Cancer</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Emmanuel S. Antonarakis, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Treating Castration-Resistant Prostate Cancer</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Emmanuel S. Antonarakis, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Radiation Therapy Following Prostate Cancer Surgery</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by H. Ballentine Carter, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Treating Prostate Cancer After Brachytherapy Failure</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Theodore L. DeWeese, M.D., and Danny Song, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>New Therapies That May Change the Course of Treatment</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Emmanuel S. Antonarakis, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>How to Best Preserve Skeletal Health</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Emmanuel S. Antonarakis, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Treating the Pain of Advanced Prostate Cancer</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Emmanuel S. Antonarakis, M.D. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>The Anatomy of Hope</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'> by Jerome Groopman, M.D. In The Anatomy of Hope, Dr. Groopman offers his own experiences of coping with debilitating pain for nearly two decades, and how hope differs from optimism. He outlines how hope can be an essential part of treating advanced prostate cancer successfully. <o:p></o:p></span></li><li class=MsoNormal style='color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:13.5pt;mso-list:l2 level1 lfo6'><span style='font-size:9.0pt;font-family:"Arial","sans-serif"'>In <strong><span style='font-family:"Arial","sans-serif"'>On End-of-Life Decisions</span></strong> by Virginia Morris. <em><span style='font-family:"Arial","sans-serif"'>On End-of-Life Decisions</span></em>, award-winning journalist Virginia Morris takes us through her father's eventual passing from prostate cancer, and offers invaluable guidelines on how to deal with end of life decisions even as you deal with your advanced prostate cancer treatment decisions, in order to ensure that all your personal as well as medical wishes are carried out appropriately. <o:p></o:p></span></li></ul><p style='line-height:13.5pt'><strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Advanced Prostate Cancer Treatments</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'> also includes a 10-page glossary to help you understand the technical terms used in the Special Health Report.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>About Scientific American -- Experts in Science, Technology and Health</span></strong><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Science is at the forefront of advances in the understanding and treatment of prostate disorders and other serious diseases. 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Our broad international reach enables us to deliver to our readers scientific developments in medical research as they happen and to explain how these advances will impact the health and condition management of our readership.<o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>You can count on Scientific American Special Health Reports to bring you medical information that is trustworthy, impeccably researched and current.<o:p></o:p></span></p><p class=center align=center style='text-align:center;line-height:13.5pt'><strong><span style='font-family:"Arial","sans-serif";color:black'>Download Your Copy Today and Get Our No-Strings,</span></strong><b><span style='font-family:"Arial","sans-serif";color:black'><br><strong><span style='font-family:"Arial","sans-serif"'>Can't Lose, Must-Be-Satisfied Guarantee</span></strong></span></b><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p><p style='line-height:13.5pt'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:black'>Don't hesitate. 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