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</o:shapelayout></xml><![endif]--></head><body bgcolor="#F0F1F2" lang=EN-CA link="#295AA6" vlink="#295AA6"><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Scroll down thru the articles to the 2<sup>nd</sup> one on PCa.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Cancer Network [mailto:cancernetwork@email.cmpmedica-usa.com] <br><b>Sent:</b> December 28, 2017 10:02 AM<br><b>To:</b> glen46nor@gmail.com<br><b>Subject:</b> ONCOLOGY: Which Prostate Cancer Patients Get Sipuleucel-T?<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><div><p class=MsoNormal><span style='font-size:1.0pt'>Plus novel staging for oropharyngeal SCC based on HPV status<o:p></o:p></span></p></div><div id=wrapper><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td style='padding:0cm 0cm 0cm 0cm'><p class=MsoNormal align=center style='margin-bottom:12.0pt;text-align:center'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:#333333'>To view this email as a web page, click <a href="http://view.email.cmpmedica-usa.com/?qs=11d56dc12bbff926a6506cdb742ab3e989f2b8419e1c7ce506333a1e58f7d0f60bd728490cfdd71780cd7be8fbea49a9aef13d9cf07696cafb76512b8b477482f367d426194ada93"><b><span style='font-size:8.5pt;color:#056C9C'>here.</span></b></a></span><o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#333333;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#333333;border-collapse:collapse'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><img border=0 width=220 id=networkLogo src="http://www.ubmmedica.com/wp-content/uploads/2016/11/ModernMedicineNetwork-small.png" alt="Modern Medicine Network"><o:p></o:p></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1acf0b4fa38dc89db91c9a8b7d6472c233e060a7baf2f2e6aa7e0d93520aec1835bde00a803236e80e"><span style='text-decoration:none'><img border=0 width=360 id=logo src="http://images.ubmmedica.com/newsletters/Logos/CancerNetworkLogo.png" alt="Cancer Network home of the Journal ONCOLOGY"></span></a><o:p></o:p></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#1A357D;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr><td style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal><span style='font-family:"Arial","sans-serif";color:white'>ONCOLOGY | December 28, 2017 <o:p></o:p></span></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width=150 style='width:112.5pt;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1af5153fa6a6dc5629586b2f190f1a506fb04fb8ac85a360bd72c7e44effa73d7861b04f304f7eaf67"><span style='text-decoration:none'><img border=0 width=150 id="_x0000_i1027" src="http://content.ubmlifesciences.com/sites/default/files/onc-cover-201712-250.jpg" alt="ONCOLOGY Journal cover"></span></a><o:p></o:p></p></td></tr></table><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="65%" style='width:65.0%;border-collapse:collapse'><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#333333'>ONCOLOGY: Practical, Peer-Reviewed Perspectives<o:p></o:p></span></b></p></td></tr><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Volume 31, Number 12<o:p></o:p></span></p></td></tr><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Click <a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1af5153fa6a6dc5629586b2f190f1a506fb04fb8ac85a360bd72c7e44effa73d7861b04f304f7eaf67"><span style='color:#056C9C'>here</span></a> to view the full table of contents. <br><br>Click <a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1aff70b246f09980f272f8a9543e51a409578278c5014d94c635546fb5d1da2b2811b4785369b7fb37"><span style='color:#056C9C'>here</span></a> for the Digital Edition.<o:p></o:p></span></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'></td></tr></table></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0'><tr><td style='background:#1F7887;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:15.0pt;font-family:"Arial","sans-serif";color:white'>REVIEW ARTICLE<o:p></o:p></span></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td valign=top style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width=270 style='width:202.5pt;border-collapse:collapse;border-spacing: 0' id=articles><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1a4081c75353e76a40ab99701da57a0102afaf9dcd5c42e3752d19d63e0db6789b9ef19a19ae96a511"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Emergence of a Novel Staging System for Oropharyngeal Squamous Cell Carcinoma Based on HPV Status</span></b></a> <o:p></o:p></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><img width=70 height=70 src="http://www.cancernetwork.com/sites/default/files/onc-122017-opscc.jpg" align=left hspace=5 vspace=5 v:shapes="_x0000_s1026"><![endif]><em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Aru Panwar, MD, Erik Interval, MD, and William M. Lydiatt, MD, EMBA</span></em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'><br>The staging of oropharyngeal squamous cell carcinoma has undergone key changes in the eighth edition of the American Joint Committee on Cancer Staging Manual, set to take effect January 1, 2018. We describe the revised staging parameters and the rationale in support of the changes. <o:p></o:p></span></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1a4081c75353e76a40ab99701da57a0102afaf9dcd5c42e3752d19d63e0db6789b9ef19a19ae96a511"><span style='font-family:"Arial","sans-serif";color:#056C9C'> Read more </span></a> <o:p></o:p></p></td></tr><tr style='height:1.5pt'><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr></table><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 align=right width=300 style='width:225.0pt;border-collapse:collapse;border:none;margin-top:2.75pt;margin-bottom:2.75pt'><tr><td style='border:none;border-left:solid #F0F1F2 1.5pt;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:8.5pt;font-family:"Arial","sans-serif";color:#333333'>ADVERTISEMENT <o:p></o:p></span></p></td></tr><tr><td style='border:none;border-left:solid #F0F1F2 1.5pt;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><b><span style='font-size:14.5pt;font-family:"Arial","sans-serif";color:#575452'><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1aea006f19b5f2c61241d162d07a96243b9a7131885c4c4c5a1d3d5408863362ed4f59e0318f97ef96"></a></span></b><!--[if gte vml 1]><v:shape id="advertisement" o:spid="_x0000_s1027" type="#_x0000_t75" alt="" href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1aea006f19b5f2c61241d162d07a96243b9a7131885c4c4c5a1d3d5408863362ed4f59e0318f97ef96" style='position:absolute;margin-left:173.8pt;margin-top:0;width:225pt;height:187.5pt;z-index:251659264;mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0;mso-wrap-distance-bottom:0;mso-position-horizontal:right;mso-position-horizontal-relative:text;mso-position-vertical-relative:line' o:allowoverlap="f" o:button="t">
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</v:shape><![endif]--><![if !vml]><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1aea006f19b5f2c61241d162d07a96243b9a7131885c4c4c5a1d3d5408863362ed4f59e0318f97ef96"><img border=0 width=300 height=250 src="http://oascnx15005.247realmedia.com/RealMedia/ads/adstream_nx.ads/cancernetworkEnews/CN/RS/12282017/112282017@x30?_RM_NX_ID_=112282017" align=right v:shapes="advertisement"></a><![endif]><b><span style='font-size:14.5pt;font-family:"Arial","sans-serif";color:#575452'><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1aea006f19b5f2c61241d162d07a96243b9a7131885c4c4c5a1d3d5408863362ed4f59e0318f97ef96"><span style='text-decoration:none'><img border=0 width=1 height=1 id="_x0000_i1028" src="https://ad.doubleclick.net/ddm/trackimp/N8276.131798.CANCERNETWORK/B20415487.207493202;dc_trk_aid=407224986;dc_trk_cid=94252091;ord=12345678;dc_lat=;dc_rdid=;tag_for_child_directed_treatment=?" alt=Advertisement></span></a></span></b><b><span style='font-size:14.5pt;font-family:"Arial","sans-serif";color:#575452'><o:p></o:p></span></b></p></td></tr></table></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0'><tr><td style='background:#1F7887;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:15.0pt;font-family:"Arial","sans-serif";color:white'>HOW AN EXPERT APPROACHES IT<o:p></o:p></span></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;border-collapse:collapse;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1ac2b32eacf65ee2598ad409c32124e0757ce51c789cea3379202217684a641ed420d561f9671e1964"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Sipuleucel-T: When and for Whom to Recommend It</span></b></a> <o:p></o:p></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;border-spacing: 0' id=articles><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><!--[if gte vml 1]><v:shape id="_x0000_s1028" type="#_x0000_t75" alt="" style='position:absolute;margin-left:0;margin-top:0;width:52.5pt;height:52.5pt;z-index:251660288;mso-wrap-distance-left:3.75pt;mso-wrap-distance-top:3.75pt;mso-wrap-distance-right:3.75pt;mso-wrap-distance-bottom:3.75pt;mso-position-horizontal:left;mso-position-horizontal-relative:text;mso-position-vertical-relative:line' o:allowoverlap="f">
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</v:shape><![endif]--><![if !vml]><img width=70 height=70 src="http://www.cancernetwork.com/sites/default/files/treat-122017-150.jpg" align=left hspace=5 vspace=5 v:shapes="_x0000_s1028"><![endif]><em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Susan F. Slovin, MD, PhD</span></em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'><br>Multiple immunotherapy platforms have been investigated for prostate cancer, but sipuleucel-T still remains the sole approved autologous cellular immune product that can be used in men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer.<br><br></span><span style='font-size:12.5pt;font-family:"Arial","sans-serif";color:#333333'><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1ac2b32eacf65ee2598ad409c32124e0757ce51c789cea3379202217684a641ed420d561f9671e1964"><span style='color:#056C9C'> Read more </span></a></span><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'> <o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='background:#EEEEEE;padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#EEEEEE;border-collapse:collapse;border-spacing: 0'><tr><td style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:8.5pt;font-family:"Arial","sans-serif";color:#333333'>ADVERTISEMENT <o:p></o:p></span></p></td></tr><tr><td style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1a7e04024f3ba407c3bdf65def2946dbf2f410dd1643f92ac5cfa6abfc87c6609989466f3f5c5cad45"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Understanding disease biology in multiple myeloma progression</span></b></a> <o:p></o:p></p></td></tr><tr><td valign=top style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>In this <a href="http://click.email.cmpmedica-usa.com/?qs=1649a244dfe82f1a7e04024f3ba407c3bdf65def2946dbf2f410dd1643f92ac5cfa6abfc87c6609989466f3f5c5cad45" target="_blank">video</a>, learn about the biology of minimal residual disease cells and its impact on monitoring disease progression. <o:p></o:p></span></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#EEEEEE;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr></table></div></td></tr></table><p class=MsoNormal style='background:#F0F1F2'><o:p> </o:p></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#323232'><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#323232'><tr><td style='border:none;border-bottom:solid #555555 2.25pt;padding:7.5pt 7.5pt 7.5pt 7.5pt'><p style='line-height:140%'><b><span style='font-size:9.0pt;line-height:140%;font-family:"Arial","sans-serif";color:#888888'>This is a post-only, outbound email. 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