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</o:shapelayout></xml><![endif]--></head><body bgcolor="#F0F1F2" lang=EN-CA link="#295AA6" vlink="#295AA6"><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>See 2<sup>nd</sup> article below.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Thx.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span lang=EN-US style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Cancer Network [mailto:cancernetwork@email.cmpmedica-usa.com] <br><b>Sent:</b> February 15, 2018 10:32 AM<br><b>To:</b> glen46nor@gmail.com<br><b>Subject:</b> Pazopanib Tops Temsirolimus in Intermediate-Risk RCC<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><div><p class=MsoNormal><span style='font-size:1.0pt'>Plus: Adjuvant vs salvage radiotherapy in high-risk prostate cancer<o:p></o:p></span></p></div><div id=wrapper><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td style='padding:0cm 0cm 0cm 0cm'><p class=MsoNormal align=center style='margin-bottom:12.0pt;text-align:center'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:#333333'>To view this email as a web page, click <a href="http://view.email.cmpmedica-usa.com/?qs=2c96db2274c22ced26aa491eb211b83928c0be30b67e26577547b2e46ed1146beb34c00953bf96b92af36f6214574c8d82e15ad90628ab6d462c6146114d6e13f256da1123712a77f34c27da99bc2c57"><b><span style='font-size:8.5pt;color:#056C9C'>here.</span></b></a></span><o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#333333;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#333333;border-collapse:collapse'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><img border=0 width=220 id=networkLogo src="http://www.ubmmedica.com/wp-content/uploads/2016/11/ModernMedicineNetwork-small.png" alt="Modern Medicine Network"><o:p></o:p></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab92376f5977cba0d1b20073e81e1fd04e44ee7e990ec0a978e3d7764f607faddf0ef04d1b59b0cb59838b8"><span style='text-decoration:none'><img border=0 width=360 id=logo src="http://images.ubmmedica.com/newsletters/Logos/CancerNetworkLogo.png" alt="Cancer Network"></span></a><o:p></o:p></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#1A357D;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr><td style='padding:7.5pt 7.5pt 7.5pt 7.5pt'><p class=MsoNormal><span style='font-size:9.5pt;font-family:"Arial","sans-serif";color:white'>HIGHLIGHTS | February 15, 2018 <o:p></o:p></span></p></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;border-collapse:collapse;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab9237669bf9f8a4d72b12446abc03cd9129d9b6ea22339a17d71209e5b98546b0bdc630f4751bccbd048fd"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Pazopanib Tops Temsirolimus in Intermediate-Risk Clear Cell RCC</span></b></a> <o:p></o:p></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;border-spacing: 0' id=articles><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Pazopanib was not associated with prolonged progression-free survival compared with temsirolimus among patients with advanced clear-cell renal cell carcinoma, but a subgroup analysis of intermediate-risk patients offered some reason for optimism.<br><br></span><span style='font-size:12.5pt;font-family:"Arial","sans-serif";color:#333333'><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab9237676b674f189b74a7f08f61d97bf5ed34f4a506768c2b1bdd924f703984a427817662192acce9606a8"><span style='color:#056C9C'> Read more </span></a></span><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'> <o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;border-collapse:collapse;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab923769a1458708ab402d3ba62fccd78b3461a5246d30b4474684e3db783564a50f589b36059aa73c3d47f"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Adjuvant vs Salvage Radiotherapy in High-Risk Prostate Cancer</span></b></a> <o:p></o:p></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;border-spacing: 0' id=articles><tr><td valign=top style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Adjuvant radiotherapy after prostatectomy resulted in lower rates of biochemical recurrence, distant metastases, and death compared with surveillance followed by early-salvage radiotherapy in patients with high-risk prostate cancer, according to a new study.<br><br></span><span style='font-size:12.5pt;font-family:"Arial","sans-serif";color:#333333'><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab923769a1458708ab402d3ba62fccd78b3461a5246d30b4474684e3db783564a50f589b36059aa73c3d47f"><span style='color:#056C9C'> Read more </span></a></span><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'> <o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0'><tr><td style='background:#1F7887;padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:15.0pt;font-family:"Arial","sans-serif";color:white'>TEST YOUR IMAGE IQ <o:p></o:p></span></p></td></tr></table></div></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;border-collapse:collapse;border-spacing: 0'><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab92376fafb9ab0208dd83ad964b50e0afc8ed99775c6c2e4103b9d12f24234e99c3e7e8855a6813dbd6034"><b><span style='font-size:14.0pt;font-family:"Arial","sans-serif";color:#056C9C'>Mass Found in Adrenal Gland of 52-Year-Old Patient</span></b></a> <o:p></o:p></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;border-spacing: 0' id=articles><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><img width=70 height=70 src="http://content.ubmlifesciences.com/sites/default/files/styles/media_thumbnail/public/moran-adrenal-52-20180208.jpg" align=left hspace=5 vspace=5 v:shapes="_x0000_s1026"><![endif]><em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'>Cesar A. Moran, MD</span></em><span style='font-size:11.0pt;font-family:"Arial","sans-serif";color:#333333'><br>A 52-year-old man presents with a mass in his right adrenal gland, and a biopsy is performed. <br><br><br><strong><span style='font-family:"Arial","sans-serif"'>What is the diagnosis?</span></strong><br>A. Adrenocortical hyperplasia<br>B. Angiosarcoma<br>C. Hemorrhagic pseudocyst<br>D. Addison disease <o:p></o:p></span></p></td></tr><tr><td style='padding:3.75pt 3.75pt 3.75pt 3.75pt'><p class=MsoNormal><a href="http://click.email.cmpmedica-usa.com/?qs=72cd67765ab923764b25e2339406db5bcfa0a3df18ac2cb3427402491ee46edf2c81631a29d7283299761d5e77712013"><span style='font-family:"Arial","sans-serif";color:#056C9C'> Click here to choose your answer </span></a> <o:p></o:p></p></td></tr></table></td></tr></table></td></tr></table></div><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:white;border-collapse:collapse;border-spacing: 0;min-width: 600px'><tr style='height:1.5pt'><td style='padding:0cm 0cm 0cm 0cm;height:1.5pt'><p class=MsoNormal style='mso-line-height-alt:1.5pt'> <o:p></o:p></p></td></tr></table></div></td></tr></table><p class=MsoNormal style='background:#F0F1F2'><o:p> </o:p></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#323232'><tr><td style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;background:#323232'><tr><td style='border:none;border-bottom:solid #555555 2.25pt;padding:7.5pt 7.5pt 7.5pt 7.5pt'><p style='line-height:140%'><b><span style='font-size:9.0pt;line-height:140%;font-family:"Arial","sans-serif";color:#888888'>This is a post-only, outbound email. 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