<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=utf-8"><meta name=Generator content="Microsoft Word 12 (filtered medium)"><!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><title> </title><style><!--
/* Font Definitions */
@font-face
{font-family:Helvetica;
panose-1:2 11 6 4 2 2 2 2 2 4;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
h1
{mso-style-priority:9;
mso-style-link:"Heading 1 Char";
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:24.0pt;
font-family:"Times New Roman","serif";
font-weight:bold;}
h2
{mso-style-priority:9;
mso-style-link:"Heading 2 Char";
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:18.0pt;
font-family:"Times New Roman","serif";
font-weight:bold;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p
{mso-style-priority:99;
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
{mso-style-priority:99;
mso-style-link:"Balloon Text Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:8.0pt;
font-family:"Tahoma","sans-serif";}
span.Heading1Char
{mso-style-name:"Heading 1 Char";
mso-style-priority:9;
mso-style-link:"Heading 1";
font-family:"Cambria","serif";
color:#365F91;
font-weight:bold;}
span.Heading2Char
{mso-style-name:"Heading 2 Char";
mso-style-priority:9;
mso-style-link:"Heading 2";
font-family:"Cambria","serif";
color:#4F81BD;
font-weight:bold;}
span.item-citation
{mso-style-name:item-citation;}
p.author-group, li.author-group, div.author-group
{mso-style-name:author-group;
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.authors
{mso-style-name:authors;}
span.author-group-text
{mso-style-name:author-group-text;}
span.author
{mso-style-name:author;}
p.utility-action-list, li.utility-action-list, div.utility-action-list
{mso-style-name:utility-action-list;
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.utility-action-link
{mso-style-name:utility-action-link;}
span.divider
{mso-style-name:divider;}
span.BalloonTextChar
{mso-style-name:"Balloon Text Char";
mso-style-priority:99;
mso-style-link:"Balloon Text";
font-family:"Tahoma","sans-serif";}
span.EmailStyle30
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1028" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>See below for several PCa related articles.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Thx to Michael Wilson for sharing them.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Take care,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p><blockquote style='margin-top:5.0pt;margin-bottom:5.0pt'><div><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#9594A0;border-collapse:collapse'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm'></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#16799A;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><tr><td valign=top style='padding:7.5pt 0cm 0cm 0cm;min-width: 580px'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><tr><td width="66%" valign=top style='width:66.66%;padding:0cm 7.5pt 7.5pt 0cm;border-spacing: 0'><h1 style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:28.5pt;font-family:"Helvetica","sans-serif";color:white;font-weight:normal'>Week in Review <o:p></o:p></span></h1><h2 style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:15.0pt;font-family:"Helvetica","sans-serif";color:white;font-weight:normal'>Advanced Prostate Cancer <o:p></o:p></span></h2></td><td width="33%" style='width:33.32%;padding:0cm 0cm 7.5pt 0cm;min-width: 0;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><p class=MsoNormal align=right style='text-align:right;line-height:14.25pt'><a name="www_practiceupdate_com_elsca1_"></a><a href="http://links.mkt1881.com/ctt?kn=6&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=PU></a><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
<v:stroke joinstyle="miter" />
<v:formulas>
<v:f eqn="if lineDrawn pixelLineWidth 0" />
<v:f eqn="sum @0 1 0" />
<v:f eqn="sum 0 0 @1" />
<v:f eqn="prod @2 1 2" />
<v:f eqn="prod @3 21600 pixelWidth" />
<v:f eqn="prod @3 21600 pixelHeight" />
<v:f eqn="sum @0 0 1" />
<v:f eqn="prod @6 1 2" />
<v:f eqn="prod @7 21600 pixelWidth" />
<v:f eqn="sum @8 21600 0" />
<v:f eqn="prod @7 21600 pixelHeight" />
<v:f eqn="sum @10 21600 0" />
</v:formulas>
<v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect" />
<o:lock v:ext="edit" aspectratio="t" />
</v:shapetype><v:shape id="_x0000_s1026" type="#_x0000_t75" alt="Practice Update" href="http://links.mkt1881.com/ctt?kn=6&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=""PU"" style='position:absolute;left:0;text-align:left;margin-left:0;margin-top:0;width:132pt;height:30pt;z-index:251658240;mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0;mso-wrap-distance-bottom:0;mso-position-horizontal:left;mso-position-horizontal-relative:text;mso-position-vertical-relative:line' o:allowoverlap="f" o:button="t">
<v:imagedata src="https://d2ogjlfjkptkow.cloudfront.net/punewsletter/general/logo-practiceupdate-inverse.gif" />
<w:wrap type="square"/>
</v:shape><![endif]--><![if !vml]><a href="http://links.mkt1881.com/ctt?kn=6&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=""PU""><img border=0 width=176 height=40 src="https://d2ogjlfjkptkow.cloudfront.net/punewsletter/general/logo-practiceupdate-inverse.gif" align=left alt="Practice Update" v:shapes="_x0000_s1026"></a><![endif]><a href="http://links.mkt1881.com/ctt?kn=6&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=PU></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p></o:p></span></p></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto;visibility:hidden'></td></tr></table></td></tr></table></div></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt'><tr><td style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%'><tr style='height:3.75pt'><td style='background:white;padding:0cm 0cm 0cm 0cm;height:3.75pt'></td></tr><tr><td style='background:white;padding:0cm 0cm 0cm 0cm'><p class=MsoNormal><!--[if gte vml 1]><v:shape id="_x0000_s1027" type="#_x0000_t75" alt="" style='position:absolute;margin-left:0;margin-top:0;width:50.25pt;height:6pt;z-index:251659264;mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0;mso-wrap-distance-bottom:0;mso-position-horizontal:left;mso-position-horizontal-relative:text;mso-position-vertical-relative:line' o:allowoverlap="f">
<v:imagedata src="https://d2ogjlfjkptkow.cloudfront.net/punewsletter/general/ad-notice.gif" />
<w:wrap type="square"/>
</v:shape><![endif]--><![if !vml]><img width=67 height=8 src="https://d2ogjlfjkptkow.cloudfront.net/punewsletter/general/ad-notice.gif" align=left v:shapes="_x0000_s1027"><![endif]><o:p></o:p></p></td></tr><tr><td style='background:white;padding:0cm 0cm 0cm 0cm'><p class=MsoNormal><a name="pubads_g_doubleclick_net_gampa"></a><a href="http://pubads.g.doubleclick.net/gampad/jump?co=1&iu=/6053/els.pracupadvancedprostatecancer/email/weekinreview&sz=728x90&t=day%3D20%26month%3D07%26year%3D2018"><span style='text-decoration:none'><img border=0 id="_x0000_i1025" src="http://pubads.g.doubleclick.net/gampad/ad?co=1&iu=/6053/els.pracupadvancedprostatecancer/email/weekinreview&sz=728x90&t=day%3D20%26month%3D07%26year%3D2018"></span></a><o:p></o:p></p></td></tr><tr style='height:3.75pt'><td style='background:white;padding:0cm 0cm 0cm 0cm;height:3.75pt'></td></tr></table></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;text-align:inherit;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm;hyphens: auto;word-break:break-word;-moz-hyphens: auto;-webkit-hyphens: auto'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;hyphens: auto;word-break:break-word;-moz-hyphens: auto;-webkit-hyphens: auto'><tr><td style='padding:0cm 0cm 0cm 0cm;border-spacing: 0'></td></tr><tr><td valign=top style='padding:7.5pt 0cm 0cm 0cm;hyphens: auto;word-break:break-word;-moz-hyphens: auto;-webkit-hyphens: auto'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:14.25pt'><a name="www_practiceupdate_com_c_70512"></a><a href="http://links.mkt1881.com/ctt?kn=11&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=PU><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#16799A;text-decoration:none'>Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial </span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><br></span><span class=item-citation><span style='font-size:8.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>2018 Jul 16 </span></span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><hr size=1 width="100%" noshade style='color:#D9D9D9' align=center></span></div><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:14.25pt'><a name="www_practiceupdate_com_c_70540"></a><a href="http://links.mkt1881.com/ctt?kn=3&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=PU><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#16799A;text-decoration:none'>New-Onset Diabetes After Androgen-Deprivation Therapy for Prostate Cancer: A Nationwide Propensity Score-Matched Four-Year Longitudinal Cohort Study </span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><br></span><span class=item-citation><span style='font-size:8.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>2018 Jul 16 </span></span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><o:p></o:p></span></p><div class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><hr size=1 width="100%" noshade style='color:#D9D9D9' align=center></span></div><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:14.25pt'><a name="www_practiceupdate_com_c_70999"></a><a href="http://links.mkt1881.com/ctt?kn=10&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target=PU><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#16799A;text-decoration:none'>The Androgen Receptor Inhibitor Enzalutamide Is Approved for Castration-Resistant, Nonmetastatic Prostate Cancer </span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><br></span><span class=item-citation><span style='font-size:8.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>2018 Jul 19 </span></span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><o:p></o:p></span></p><p class=author-group style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:14.25pt'><span class=author-group-text><i><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>Commentary by </span></i></span><span class=author><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>Brian Lewis MD, MPH</span></span><span class=authors><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'> </span></span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#776F67'><o:p></o:p></span></p></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;hyphens: auto;word-break:break-word;-moz-hyphens: auto;-webkit-hyphens: auto;visibility:hidden'></td></tr></table></td></tr></table></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><tr><td valign=top style='padding:7.5pt 0cm 0cm 0cm;min-width: 580px'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:7.5pt;font-family:"Helvetica","sans-serif";color:#776F67'>You're receiving this newsletter because you subscribed to Advanced Prostate Cancer : Week in Review </span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><br><br><o:p></o:p></span></p></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto;visibility:hidden'></td></tr></table></td></tr></table></div></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='padding:7.5pt 15.0pt 0cm 0cm;min-width: 580px'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=130 style='width:97.5pt;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='border:solid #D0D0D0 1.0pt;background:#E9E9E9;padding:3.75pt 0cm 3.0pt 0cm;border-spacing: 0;overflow:hidden'><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><a name="www_facebook_com_practiceupdat"></a><a href="http://links.mkt1881.com/ctt?kn=12&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target="_blank"><span style='font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#555555;text-decoration:none'>facebook</span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#555555'> <o:p></o:p></span></p></td></tr></table></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word;visibility:hidden'></td></tr></table></td><td valign=top style='padding:7.5pt 15.0pt 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=130 style='width:97.5pt;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='border:solid #D0D0D0 1.0pt;background:#E9E9E9;padding:3.75pt 0cm 3.0pt 0cm;border-spacing: 0;overflow:hidden'><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><a name="www_twitter_com_practiceupdate"></a><a href="http://links.mkt1881.com/ctt?kn=9&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target="_blank"><span style='font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#555555;text-decoration:none'>twitter</span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#555555'> <o:p></o:p></span></p></td></tr></table></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word;visibility:hidden'></td></tr></table></td><td valign=top style='padding:7.5pt 15.0pt 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=130 style='width:97.5pt;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='border:solid #D0D0D0 1.0pt;background:#E9E9E9;padding:3.75pt 0cm 3.0pt 0cm;border-spacing: 0;overflow:hidden'><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><a name="plus_google_com__practiceupdat"></a><a href="http://links.mkt1881.com/ctt?kn=7&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target="_blank"><span style='font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#555555;text-decoration:none'>google+</span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#555555'> <o:p></o:p></span></p></td></tr></table></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word;visibility:hidden'></td></tr></table></td><td valign=top style='padding:7.5pt 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=130 style='width:97.5pt;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word'><tr><td valign=top style='border:solid #D0D0D0 1.0pt;background:#E9E9E9;padding:3.75pt 0cm 3.0pt 0cm;border-spacing: 0;overflow:hidden'><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><a name="www_linkedin_com_company_51430"></a><a href="http://links.mkt1881.com/ctt?kn=8&ms=NTcwMzE0MDcS1&r=MzQzMzY2NTY4OTMxS0&b=0&j=MTQ0MjQ0NDA0MAS2&mt=2&rj=MTQ0MjQ0NDA0MAS2&rt=0" target="_blank"><span style='font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#555555;text-decoration:none'>LinkedIn</span></a><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#555555'> <o:p></o:p></span></p></td></tr></table></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;-moz-hyphens: auto;-webkit-hyphens: auto;hyphens: auto;word-break:break-word;visibility:hidden'></td></tr></table></td></tr></table></div></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#9594A0;border-collapse:collapse;border-spacing: 0'><tr><td valign=top style='padding:7.5pt 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=580 style='width:435.0pt;border-collapse:collapse;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto'><tr><td valign=top style='padding:0cm 0cm 7.5pt 0cm;border-spacing: 0'><p class=MsoNormal align=center style='margin-bottom:12.0pt;text-align:center;line-height:14.25pt'><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><br><img border=0 id="_x0000_i1028" src="https://d2ogjlfjkptkow.cloudfront.net/punewsletter/general/elsevier-logo.gif" alt="Brought to you by Elsevier"><br></span><span style='font-size:7.5pt;font-family:"Helvetica","sans-serif";color:white'>PracticeUpdate ® is a registered trademark of Elsevier Inc. </span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><br></span><span style='font-size:7.5pt;font-family:"Helvetica","sans-serif";color:white'>Copyright © 2018, Elsevier Inc. All rights reserved. </span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><br></span><span style='font-size:7.5pt;font-family:"Helvetica","sans-serif";color:white'>Elsevier Inc., 1600 John F. Kennedy Boulevard, Suite 1800. Philadelphia, PA 19103-2899, USA </span><span style='font-size:10.5pt;font-family:"Helvetica","sans-serif";color:#222222'><o:p></o:p></span></p></td><td width=0 valign=top style='width:.3pt;padding:0cm 0cm 0cm 0cm;hyphens: auto;-moz-hyphens: auto;word-break:break-word;-webkit-hyphens: auto;visibility:hidden'></td></tr></table></div></td></tr></table></div></td></tr></table><p class=MsoNormal><img border=0 id="_x0000_i1029" src="http://open.mkt1881.com/open/log/57031407/MzQzMzY2NTY4OTMxS0/0/MTQ0MjQ0NDA0MAS2/2/MTQ0MjQ0NDA0MAS2/0"><o:p></o:p></p><div id="_t"><p class=MsoNormal> <o:p></o:p></p></div><p style='margin:0cm;margin-bottom:.0001pt'><img border=0 width=1 height=1 id="_x0000_i1030" src="https://87tbwoak.emltrk.com/87tbwoak?d=192804"><o:p></o:p></p></div></blockquote></div></body></html>