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</o:shapelayout></xml><![endif]--></head><body bgcolor="#E5E5E5" lang=EN-CA link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='mso-fareast-language:EN-US'>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span style='mso-fareast-language:EN-US'>If you take statins to control cholesterol scroll down to the article on “Grapefruit juice & statins”.<o:p></o:p></span></p><p class=MsoNormal><i><span style='mso-fareast-language:EN-US'>Then have a glass of red wine</span></i><span style='mso-fareast-language:EN-US'>. :>)<o:p></o:p></span></p><p class=MsoNormal><span style='mso-fareast-language:EN-US'>Take care & stay well.<o:p></o:p></span></p><p class=MsoNormal><span style='mso-fareast-language:EN-US'>Glen<o:p></o:p></span></p><p class=MsoNormal><span style='mso-fareast-language:EN-US'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal><b><span lang=EN-US>From:</span></b><span lang=EN-US> Harvard Medical School <br><b>Sent:</b> July 2, 2020 12:30 PM<br><b>To:</b> Glen <glen46nor@gmail.com><br><b>Subject:</b> Cholesterol and heart disease: The role of diet<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><div id=PreHeader><p class=MsoNormal><span style='font-family:"Arial",sans-serif'>Also: Grapefruit juice and statins.<o:p></o:p></span></p></div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><img width=1 height=1 style='width:.0104in;height:.0104in' id="_x0000_i1053" src="http://www.ne16.com/do/2275633/20302661/1000401/1.gif?x=bf5313a1"></span><span style='font-family:"Arial",sans-serif'><o:p></o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#E5E5E5;border-collapse:collapse' id=body-wrapper-table><tr><td width="100%" style='width:100.0%;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%' id=body-wrapper><div 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24.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial",sans-serif;color:black'><a href="http://www.ne16.com/t/2275633/20302661/2465835/0/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=cb34f4e0"><span style='color:#3D5D8F;text-decoration:none'>Subscribe</span></a> | <a href="http://www.ne16.com/t/2275633/20302661/2465836/0/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=cfd0ad46"><span style='color:#3D5D8F;text-decoration:none'>Shop the Bookstore</span></a><o:p></o:p></span></p></td></tr></table></td><td width=320 valign=top style='width:240.0pt;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=320 style='width:240.0pt;border-collapse:collapse'><tr><td style='background:white;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%' id=icon-block><p class=MsoNormal style='line-height:15.0pt'><span style='color:black'><a href="http://www.ne16.com/t/2275633/20302661/2465834/1/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=86355dd2"><span style='font-size:10.5pt;font-family:"Georgia",serif;text-decoration:none'><img border=0 width=320 height=107 style='width:3.3333in;height:1.1145in' id="_x0000_i1051" src="http://harvard-health.s3.amazonaws.com/images/email/logo-harvard_medical_school_mobile@2x.png" alt="Harvard Medical School"></span></a></span><span style='font-size:10.5pt;font-family:"Georgia",serif'><o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr></table></td></tr><tr><td style='border-top:none;border-left:solid #CCCCCC 1.0pt;border-bottom:solid #CCCCCC 6.0pt;border-right:solid #CCCCCC 1.0pt;background:white;padding:24.0pt 24.0pt 24.0pt 24.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left style='border-collapse:collapse'><tr><td style='background:white;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm'><span style='font-size:21.0pt;font-family:"Tahoma",sans-serif;color:black;font-weight:normal'>Cholesterol and heart disease: The role of diet <o:p></o:p></span></h1><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 style='border:solid #AAAAAA 1.5pt'><tr><td style='border:none;padding:6.0pt 6.0pt 6.0pt 6.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal align=right style='margin-bottom:12.0pt;text-align:right'><img border=0 width=556 height=370 style='width:5.7916in;height:3.8541in' id="_x0000_i1050" src="https://www.health.harvard.edu/media/content/images/cr/bf926b9c-4cbf-422d-9ad0-c287ac6b17d8.jpg"><o:p></o:p></p></td></tr></table><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Your diet clearly plays a role in determining your cholesterol levels, but if you're like most people, the most important factor isn't how much cholesterol-rich food you eat. Rather, it's what <em><span style='font-family:"Tahoma",sans-serif'>else </span></em>you eat. Figuring this out has been a learning process.<o:p></o:p></span></p><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 style='background:#FEFEFE;border-collapse:collapse;border:none'><tr><td style='border:solid #AAAAAA 1.0pt;padding:12.0pt 12.0pt 12.0pt 12.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal style='margin-bottom:12.0pt'><span class=like-h3><b><span style='font-size:11.5pt;font-family:"Tahoma",sans-serif;color:black'>Get your copy of </span></b></span><em><b><span style='font-size:11.5pt;font-family:"Tahoma",sans-serif;color:black'>Managing Your Cholesterol</span></b></em><span style='font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black'><br> <o:p></o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left style='border-collapse:collapse'><tr><td width=113 valign=top style='width:84.75pt;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse'><tr><td style='background:#FEFEFE;padding:.75pt .75pt .75pt .75pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span style='color:black'><a href="http://www.ne16.com/t/2275633/20302661/2491259/0/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=a53be332"><span style='color:#3D5D8F;text-decoration:none'><img border=0 width=100 height=130 style='width:1.0416in;height:1.3541in' id="_x0000_i1049" src="https://www.health.harvard.edu/media/content/images/products/cover/Cholesterol_HC0519_Cover.jpg" alt="Managing Your Cholesterol"></span></a></span><o:p></o:p></p></td></tr></table></td><td valign=top style='padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><em><span style='font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black'>Managing Your Cholesterol</span></em><span style='font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black'> offers up-to-date information to help you or a loved one keep cholesterol in check. The report spells out what are healthy and unhealthy cholesterol levels, and offers specific ways to keep cholesterol in line. It covers cholesterol tests and the genetics of cholesterol. The report also focuses on treatments based on the latest scientific evidence, including the pros and cons of statins and other medications, and provides the lowdown on other substances advertised to lower cholesterol. <em><span style='font-family:"Tahoma",sans-serif'>Managing Your Cholesterol</span></em> can also help you work with your doctor to individualize your treatment.<br><br></span><a href="http://www.ne16.com/t/2275633/20302661/2491259/1/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=0a991cdf"><span style='font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#3D5D8F;text-decoration:none'><img border=0 width=176 height=26 style='width:1.8333in;height:.2708in' id="_x0000_i1048" src="http://harvard-health.s3.amazonaws.com/images/email/button-read_more-2@2x.png" alt="Read More"></span></a><span style='font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black'><o:p></o:p></span></p></td></tr></table></td></tr></table><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Initially, the news that cholesterol in the bloodstream was linked to heart disease prompted an all-out war on cholesterol in food. From the 1960s on, people were advised to stay away from foods rich in cholesterol, like eggs, dairy foods, and some types of seafood. But today, the science suggests that, for most people, dietary cholesterol (the cholesterol in foods) has only a modest effect on the amount of cholesterol in the bloodstream. In fact, the 2015–2020 Dietary Guidelines for Americans eliminated an earlier recommendation to limit dietary cholesterol to 300 milligrams (mg) per day—although they still suggest caution on overall intake.<o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Notably, the guidelines did not change the recommendation on saturated fat, which is found mainly in animal-based foods such as meat and dairy—and is often found in high-cholesterol foods. Saturated fat in the diet clearly <em><span style='font-family:"Tahoma",sans-serif'>does </span></em>raise LDL by a significant amount and should still be consumed in limited quantities. And although some research has cast doubt on the conventional wisdom that saturated fat is linked with heart disease, other research upholds the link.<o:p></o:p></span></p><h3><strong><span style='font-family:"Tahoma",sans-serif;color:#4D4D4F'>Foods high in fiber, low in saturated fat can lower cholesterol</span></strong><span style='font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></h3><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>While saturated fat and dietary cholesterol both play a role in your cholesterol level, experts stress that the most important dietary change you can make to lower your cholesterol numbers is to adjust the overall pattern of your diet. Best is a diet rich in fruits, vegetables, fish, and whole grains. This helps in two ways. First, the more of these healthful foods you eat, the less you generally consume of foods that are high in saturated fat and highly refined carbohydrates, which both damage the cardiovascular system. Second, high-fiber foods help reduce your cholesterol level by making unhealthy dietary fats harder to absorb from the gut.<o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>This doesn't work for everyone, however. For people at high risk of heart disease, dietary efforts don't come close to lowering cholesterol enough. Other people are genetically predisposed to having high blood cholesterol regardless of what they eat.<o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>To learn more about cholesterol and heart disease, read <a href="http://www.ne16.com/t/2275633/20302661/2491259/2/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=5a0052e1" target="_blank"><span style='color:#3D5D8F'>Managing Your Cholesterol</span></a>, a Special Health Report from Harvard Medical School.</span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:8.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Image: © udra | Getty Images</span></strong><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'> </span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></p><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 style='background:#EFEFEF;border-collapse:collapse;border:none'><tr><td style='border:solid #CCCCCC 1.0pt;border-right:none;padding:2.25pt 2.25pt 2.25pt 12.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span class=rbi-text><b><span style='font-size:10.0pt;color:black'>Share this story:</span></b></span><o:p></o:p></p></td><td style='border:solid #CCCCCC 1.0pt;border-left:none;padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=60 style='width:45.0pt;border-collapse:collapse'><tr><td style='padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><a href="http://www.ne16.com/t/2275633/20302661/2654390/0/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=d167eb57"><span style='text-decoration:none'><img border=0 width=24 height=24 style='width:.25in;height:.25in' id="_x0000_i1047" src="http://harvard-health.s3.amazonaws.com/images/email/icon-social-facebook@2x.png" alt="Share on Facebook"></span></a><o:p></o:p></p></td><td style='padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><a href="http://www.ne16.com/t/2275633/20302661/2654391/0/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=d43e3680"><span style='color:#3D5D8F;border:none windowtext 1.0pt;padding:0cm;text-decoration:none'><img border=0 width=24 height=24 style='width:.25in;height:.25in' id="_x0000_i1046" src="http://harvard-health.s3.amazonaws.com/images/email/icon-social-twitter@2x.png" alt="Share on Twitter"></span></a><o:p></o:p></p></td></tr></table></td></tr></table></td></tr></table></td></tr><tr><td style='border-top:none;border-left:solid #CCCCCC 1.0pt;border-bottom:solid #CCCCCC 6.0pt;border-right:solid #CCCCCC 1.0pt;background:white;padding:24.0pt 24.0pt 24.0pt 24.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left style='border-collapse:collapse'><tr><td style='background:white;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm'><span style='font-size:21.0pt;font-family:"Tahoma",sans-serif;color:black;font-weight:normal'>Grapefruit juice and statins <o:p></o:p></span></h1><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 style='border:solid #AAAAAA 1.5pt'><tr><td style='border:none;padding:6.0pt 6.0pt 6.0pt 6.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal align=right style='margin-bottom:12.0pt;text-align:right'><img border=0 width=556 height=371 style='width:5.7916in;height:3.8645in' id="_x0000_i1045" src="https://www.health.harvard.edu/media/content/images/cr/faecd118-4301-4219-a3ea-ceb65db030da.jpg"><o:p></o:p></p></td></tr></table><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Q: I've heard that people shouldn't drink grapefruit juice if they're taking a statin. Why?</span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>A: </span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream. Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job. As a result, more of the drug is absorbed, making it more powerful than it's meant to be — even toxic in some cases.<o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Not all statins are affected equally by grapefruit juice, so grapefruit fans might want to switch to a statin that's less affected (see the table below). But if you can't switch, experts say it's probably okay to enjoy a small glass. That's because the studies showing dangerous effects used massive amounts of furanocoumarins, the amount found in a quart or more of the juice. What's more, eating half a grapefruit is even less risky than drinking grapefruit juice, since it takes several fruits to make a single glass of juice. But to be on the safe side, check with your doctor, and avoid taking your pills with grapefruit juice.<o:p></o:p></span></p><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0><tr style='height:39.0pt'><td width=355 colspan=2 style='width:266.25pt;padding:0cm 0cm 0cm 0cm;height:39.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-family:"Calibri",sans-serif'> The grapefruit effect</span></strong><o:p></o:p></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> Grapefruit juice affects certain statins more than others.<o:p></o:p></p></td></tr><tr style='height:27.0pt'><td width=175 style='width:131.25pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-family:"Calibri",sans-serif'> Big effect</span></strong><o:p></o:p></p></td><td width=180 style='width:135.0pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-family:"Calibri",sans-serif'> Little or no effect</span></strong><o:p></o:p></p></td></tr><tr style='height:26.25pt'><td width=175 style='width:131.25pt;padding:0cm 0cm 0cm 0cm;height:26.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> atorvastatin (Lipitor)<o:p></o:p></p></td><td width=180 style='width:135.0pt;padding:0cm 0cm 0cm 0cm;height:26.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> fluvastatin (Lescol)<o:p></o:p></p></td></tr><tr style='height:27.0pt'><td width=175 style='width:131.25pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> lovastatin (Mevacor)<o:p></o:p></p></td><td width=180 style='width:135.0pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> pitavastatin (Livalo)<o:p></o:p></p></td></tr><tr style='height:27.0pt'><td width=175 style='width:131.25pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> simvastatin (Zocor)<o:p></o:p></p></td><td width=180 style='width:135.0pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> pravastatin (Pravachol)<o:p></o:p></p></td></tr><tr style='height:27.0pt'><td width=175 style='width:131.25pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal> <o:p></o:p></p></td><td width=180 style='width:135.0pt;padding:0cm 0cm 0cm 0cm;height:27.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'> rosuvastatin (Crestor)<o:p></o:p></p></td></tr></table><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>To learn more about cholesterol and heart disease, read <a href="http://www.ne16.com/t/2275633/20302661/2491259/3/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=7dfa4e83" target="_blank"><span style='color:#3D5D8F'>Managing Your Cholesterol</span></a>, a Special Health Report from Harvard Medical School.</span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></p><p style='mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><strong><span style='font-size:8.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'>Image: Wavebreakmedia, Ltd./Getty Images</span></strong><strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'> </span></strong><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif;color:#4D4D4F'><o:p></o:p></span></p><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 style='background:#EFEFEF;border-collapse:collapse;border:none'><tr><td style='border:solid #CCCCCC 1.0pt;border-right:none;padding:2.25pt 2.25pt 2.25pt 12.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span class=rbi-text><b><span 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style='background:#CCB366;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><h2 style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:15.0pt;font-family:"Georgia",serif;color:white;font-weight:normal'>Featured in this issue<o:p></o:p></span></h2></td></tr></table></td></tr><tr><td style='border-top:none;border-left:solid #CCCCCC 1.0pt;border-bottom:none;border-right:solid #CCCCCC 1.0pt;background:#FCFAE9;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse'><tr><td style='background:#FCFAE9;padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width=640 style='width:480.0pt;border-collapse:collapse'><tr><td valign=top style='padding:0cm 0cm 0cm 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=320 style='width:240.0pt;border-collapse:collapse'><tr><td style='background:#FCFAE9;padding:24.0pt 24.0pt 24.0pt 24.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse'><tr><td style='background:#FCFAE9;padding:.75pt .75pt .75pt .75pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span style='color:black'><a href="http://www.ne16.com/t/2275633/20302661/2491259/4/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=f5b3e06e"><span style='color:#3D5D8F;text-decoration:none'><img border=0 width=254 height=330 style='width:2.6458in;height:3.4375in' id="_x0000_i1042" src="https://www.health.harvard.edu/media/content/images/products/cover/Cholesterol_HC0519_Cover.jpg"></span></a></span><o:p></o:p></p></td></tr></table></div><p class=MsoNormal align=center style='text-align:center;line-height:15.0pt'><span style='font-size:10.5pt;font-family:"Arial",sans-serif;color:black'><br></span><span style='color:black'><a href="http://www.ne16.com/t/2275633/20302661/2491259/5/1000401/?f5d63f87=SEIyMDIwMDcwMi1DaG9sZXN0ZXJvbA&b44ed14b=NDhkZGJkMjctYTRiZi00MzAyLWE4MzEtN2E4NDk1ZTUxNWMy&x=c5bb3c1a"><span style='font-size:10.5pt;font-family:"Arial",sans-serif;text-decoration:none'><img border=0 width=176 height=26 style='width:1.8333in;height:.2708in' id="_x0000_i1041" src="http://harvard-health.s3.amazonaws.com/images/email/button-read_more-2@2x.png" alt="Read
More"></span></a></span><span style='font-size:10.5pt;font-family:"Arial",sans-serif'><o:p></o:p></span></p></td></tr></table></td><td valign=top style='padding:0cm 0cm 0cm 0cm;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=320 style='width:240.0pt;border-collapse:collapse'><tr><td style='background:#FCFAE9;padding:24.0pt 24.0pt 24.0pt 24.0pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm'><span style='font-size:21.0pt;font-family:"Tahoma",sans-serif;color:black;font-weight:normal'>Managing Your Cholesterol<o:p></o:p></span></h1><h2 style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:13.5pt;font-family:"Tahoma",sans-serif;color:#B30000;font-weight:normal'>Featured content:<o:p></o:p></span></h2><p class=MsoNormal style='line-height:15.0pt'><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td width="3%" valign=top style='width:3.0%;padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif'>•<o:p></o:p></span></p></td><td width="97%" valign=top style='width:97.0%;padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Tahoma",sans-serif'>Cholesterol: Good, bad, and indifferent <o:p></o:p></span></p></td></tr><tr><td width="3%" valign=top style='width:3.0%;padding:2.25pt 2.25pt 2.25pt 2.25pt;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%'><p class=MsoNormal><span 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