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--></style></head><body lang=EN-CA link=blue vlink="#954F72" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><span class=DefaultFontHxMailStyle>Hi all:<o:p></o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle>See below for a seminar wrt Breast Screening studies.<o:p></o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle>You may wish to share this with females in your network.<o:p></o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle>Take care & stay well.<o:p></o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle><o:p> </o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle>Glen<o:p></o:p></span></p><p class=MsoNormal><span class=DefaultFontHxMailStyle><o:p> </o:p></span></p><p class=MsoNormal>Sent from <a href="https://go.microsoft.com/fwlink/?LinkId=550986">Mail</a> for Windows</p><p class=MsoNormal><span class=DefaultFontHxMailStyle><o:p> </o:p></span></p><div style='mso-element:para-border-div;border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm'><p class=MsoNormal style='border:none;padding:0cm'><b>From: </b><a href="mailto:info@survivornet.ca">Canadian Cancer Survivor Network</a><br><b>Sent: </b>October 1, 2021 3:00 PM<br><b>To: </b><a href="mailto:glen46nor@gmail.com">Glen Tolhurst</a><br><b>Subject: </b><span style='font-family:"Segoe UI Emoji",sans-serif'>🚨</span>REGISTRATION NOW OPEN - Canadian National Breast Screening Studies <span style='font-family:"Segoe UI Emoji",sans-serif'>🚨</span></p></div><p class=MsoNormal><span class=DefaultFontHxMailStyle><o:p> </o:p></span></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#015A86;border-collapse:collapse'><tr><td width="100%" valign=top style='width:100.0%;padding:7.5pt 7.5pt 7.5pt 7.5pt'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:450.0pt;border-collapse:collapse'><tr><td width=600 valign=top style='width:450.0pt;padding:0cm 0cm 0cm 0cm'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='background:#FAFAFA;padding:6.75pt 0cm 6.75pt 0cm'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='padding:6.75pt 6.75pt 6.75pt 6.75pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='padding:0cm 6.75pt 0cm 6.75pt'><p class=MsoNormal align=center style='text-align:center'><img border=0 width=564 height=188 style='width:5.875in;height:1.9583in' id="_x0000_i1027" src="https://mcusercontent.com/318d4e052fdd9593317146113/images/c5a3d3c4-49e6-4052-8bd0-9d431715e778.png"><o:p></o:p></p></td></tr></table></td></tr></table></td></tr><tr><td valign=top style='background:white;padding:6.75pt 0cm 0cm 0cm;background:cover;-webkit-text-size-adjust:100%;background-size:cover;background-position-x:50%;background-position-y:50%' id=templateHeader><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:6.75pt 6.75pt 6.75pt 6.75pt;min-width:100%;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:0cm 6.75pt 0cm 6.75pt;min-width:100%;-webkit-text-size-adjust:100%'><p class=MsoNormal align=center style='text-align:center'><img border=0 width=564 height=297 style='width:5.875in;height:3.0937in' id="_x0000_i1026" src="https://mcusercontent.com/318d4e052fdd9593317146113/images/97e97ef6-de78-723e-c905-4eb21dc574d5.png"><o:p></o:p></p></td></tr></table></td></tr></table><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%;table-layout:fixed!important'><tr><td style='padding:13.5pt 13.5pt 13.5pt 13.5pt;min-width:100%;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=1 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;border:none;min-width:100%;-webkit-text-size-adjust:100%'><tr><td style='border:none;border-top:solid #8EC63F 1.5pt;padding:0cm 0cm 0cm 0cm;min-width:100%;-webkit-text-size-adjust:100%'></td></tr></table></td></tr></table><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:0cm 13.5pt 13.5pt 13.5pt;-webkit-text-size-adjust:100%'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;background:#6FB414;border-collapse:collapse;-webkit-text-size-adjust:100%'><tr><td style='padding:11.25pt 11.25pt 11.25pt 11.25pt;border-collapse:separate!important;border-radius:3px;-webkit-text-size-adjust:100%'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'><a href="https://survivornet.us8.list-manage.com/track/click?u=318d4e052fdd9593317146113&id=e4811ce838&e=2e211ff547" title="Register Now!"><b><span style='font-family:"Calibri",sans-serif;color:white'>Register Now!</span></b></a> </span><span style='font-size:12.0pt;font-family:"Arial",sans-serif'><o:p></o:p></span></p></td></tr></table></div></td></tr></table><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:6.75pt 0cm 0cm 0cm;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse;margin-left:-2.25pt;margin-right:-2.25pt;-webkit-text-size-adjust:100%'><tr><td width=600 valign=top style='width:450.0pt;padding:0cm 0cm 0cm 0cm;max-width:100%;min-width:100%;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse;-webkit-text-size-adjust:100%;word-break:break-word'><tr><td valign=top style='padding:0cm 13.5pt 6.75pt 13.5pt'><p class=MsoNormal align=center style='text-align:center'><span style='font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#202020'><br></span><strong><span style='font-size:13.5pt;font-family:"Helvetica",sans-serif;color:#202020'>What Canadians Should Know About the</span></strong><b><span style='font-size:13.5pt;font-family:"Helvetica",sans-serif;color:#202020'><br><strong><span style='font-family:"Helvetica",sans-serif'>Canadian National Breast Screening Studies</span></strong></span></b><span style='font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#202020'><br><br></span><em><b><span style='font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#015A86'>Presented by: Daniel Kopans, MD </span></b></em><span style='font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#202020'><br><br></span><strong><span style='font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#202020'>Thursday, October 7, 2021 - 1:00-2:00 PM ET</span></strong><span style='font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#202020'><o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr></table><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:6.75pt 0cm 0cm 0cm;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse;margin-left:-2.25pt;margin-right:-2.25pt;-webkit-text-size-adjust:100%'><tr><td width=600 valign=top style='width:450.0pt;padding:0cm 0cm 0cm 0cm;max-width:100%;min-width:100%;-webkit-text-size-adjust:100%'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left width="100%" style='width:100.0%;border-collapse:collapse;-webkit-text-size-adjust:100%;word-break:break-word'><tr><td valign=top style='padding:0cm 13.5pt 6.75pt 13.5pt;-webkit-text-size-adjust:100%'><p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:150%;-webkit-text-size-adjust:100%'><strong><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#202020'>In this webinar:</span></strong><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#202020'><o:p></o:p></span></p><ol start=1 type=1><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level1 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>The Canadian National Breast Screening Studies (CNBSS) are major outliers among the Randomized, Controlled Trials (RCT) of screening (which are the only way to prove that screening saves lives). Contrary to the other RCT's which proved a benefit (lives saved) from screening women ages 40-74 (the ages of the women who participated) the CNBSS showed no benefit from screening for women at any age.<o:p></o:p></span></li><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level1 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>From the beginning there have been questions about how the trial was performed. <o:p></o:p></span></li><ul type=circle><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level2 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>Their own review showed that the quality of the mammography was "poor to unacceptable" for much of the trials. <o:p></o:p></span></li><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level2 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>They violated the fundamental rules for RCT's by examining all of the women prior to assigning them to the study arms or the control arms and then assigned women on open lists (another major violation). This provided the opportunity to assign women out of random order and "load" the screening side with women with advanced cancers biasing the results.<o:p></o:p></span></li><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level2 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>The data have always suggested an assignment imbalance. A technologist in the trial recently confirmed that this happened. By corrupting random assignment, the results of the CNBSS become unreliable.<o:p></o:p></span></li></ul><li class=MsoNormal style='color:#202020;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:150%;mso-list:l0 level1 lfo1;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif'>The results of the CNBSS should not be sued to guide screening which has been proven to save lives for women ages 40-74.<o:p></o:p></span></li></ol><p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:150%;-webkit-text-size-adjust:100%'><strong><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#202020'>About the presenter:</span></strong><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#202020'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:7.5pt;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;line-height:150%;-webkit-text-size-adjust:100%'><span style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;color:#202020'>Daniel B. Kopans, MD, is the founder of the Breast Imaging Division of the<br>Massachusetts General Hospital (MGH) and a Professor of Radiology at the Harvard Medical School. He is an internationally recognized expert in breast cancer detection and diagnosis.<br><br>An honors graduate from Harvard College and an Alpha Omega Alpha graduate of Harvard Medical School he completed a medical internship at Dartmouth Medical School and returned to Boston for his radiology training at the MGH which he completed in 1977 after which he was appointed Head of the Xeroradiography Division in 1978. He changed the name of the Division to “Breast Imaging”. His was the first “Breast Imaging” Division in the World and he gave the name to his fledgling subspecialty.<br><br>Dr. Kopans coined the name “Breast Imaging” and helped to found the new specialty. He developed Breast Imaging at the MGH from caring for 2000 women each year to over 35,000 women each year.<br><br>He is author or co-author of more than 250 scientific publications and single author of a major 1000 page textbook entitled “Breast Imaging”, now in its third edition.<br><br>In the late 1970’s Dr. Kopans recognized the importance of monitoring the outcomes of breast evaluation and developed his own, computer reporting system. He developed a structured approach to mage analysis and reporting that facilitated concise and action-oriented reports while organizing the follow-up of patients to monitor and learn from outcomes.<br><br>He was co-Chairman of the original American College of Radiology Breast Imaging Reporting and Data System (BIRADS) committee. The computerized reporting system that he developed at the MGH was the model for BIRADS promoting action-oriented reports and outcomes monitoring.<br><br>He is the inventor and led the development of Digital Breast Tomosynthesis (DBT). He convinced GE, Siemens, and Hologic of the importance of DBT and helped them develop their systems. DBT is rapidly replacing conventional 2D mammography.<br><br>Dr. Kopans has received numerous awards around the World for his work. Among many, he has been awarded the Gold Medal from the Society of Breast Imaging.<br><br>Basing his arguments on science and evidence, Dr. Kopans has been a champion of breast cancer screening and has been a major factor in preserving access for women ages 40-74 to early detection with lifesaving results.<o:p></o:p></span></p></td></tr></table></td></tr></table></td></tr></table><p class=MsoNormal><span style='display:none'><o:p> </o:p></span></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width:100%;-webkit-text-size-adjust:100%'><tr><td valign=top style='padding:0cm 13.5pt 13.5pt 13.5pt;-webkit-text-size-adjust:100%'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='background:#6FB414;border-collapse:collapse;-webkit-text-size-adjust:100%'><tr><td style='padding:11.25pt 11.25pt 11.25pt 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