[CTN] Special CTN Seminar - July 23 3:30 p.m - Masami Tatsuno

[Sue Ann Campbell]

Hello Everyone,

I hope that summer is treating you well so far.

We have a special seminar coming up in two weeks: Tuesday, July 23 at 3:30 p.m., DC1304.

The speaker is Masami Tatsuno<https://lethbridgebraindynamics.com/masami-tatsuno/> from the Department of Neuroscience at U Lethbridge.

Title: Activation of implicit memory during sleep, cell ensembles, and synaptic plasticity

Abstract:
Neural activity during rest plays an essential role in memory consolidation. Evidence has shown that explicit memory is reactivated during slow-wave sleep (SWS) and quiet wakefulness. However, there is relatively little evidence for the reactivation of implicit memory. Therefore, we have investigated the neural activity of rats’ primary motor cortex while they learn an implicit memory task. Five rats were implemented with tetrode arrays, and single-unit activity was recorded when animals performed a single pellet-reaching task. Daily recordings containing pre-task sleep, training on the reaching task, and post-task sleep continued until animals reached asymptotic performance levels. We applied PCA and found that coordinated REM and SWS activation exists and facilitates rats’ skill learning. Detection of cell ensembles using an unsupervised method also confirmed that task-associated cell ensembles were replayed during SWS and REM sleep and modulated by hippocampal sharp-wave ripples. To investigate the relationship between cell ensembles and synaptic plasticity, we have also performed numerical simulations with spiking neural networks and two STDP rules: add-STDP and log-STDP. We found that log-STDP produced considerably more cell ensembles than add-STDP. These studies provide evidence for the reactivation of implicit memory, cortico-hippocampal interaction during SWS, and a possible benefit of log-STDP for cell ensemble generation.


Regards,

Sue Ann


_______________________________________________


Dr. Sue Ann Campbell (she/her)

Professor and University Research Chair

Department of Applied Mathematics & Centre for Theoretical Neuroscience<https://uwaterloo.ca/centre-for-theoretical-neuroscience/>

Associate Dean, Research, Faculty of Mathematics

University of Waterloo

Waterloo ON N2L 3G1

https://www.math.uwaterloo.ca/~sacampbe/

President, Canadian Applied and Industrial Mathematics Society<https://caims.ca/>


I acknowledge that I live and work on the traditional territory of the Chonnonton, Anishinaabeg and Haudenosaunee peoples. The University of Waterloo main campus is located on the Haldimand tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.

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