[Hopespringpcsg] FW: FYI From renalandurologynews.com Topic: MRI Highly Accurate in Detecting Significant Prostate Cancer

[Glen Tolhurst]

Hi all:
Interesting article.

Take care,

Glen

 

August 14, 2014 


MRI Highly Accurate in Detecting Significant Prostate Cancer


Diffusion-weighted magnetic resonance imaging (DW-MRI) noninvasively detects
significant prostate tumors
<http://www.renalandurologynews.com/prostate-cancer/section/618/>  with a
high probability and without contrast medium or an endorectal coil,
according to a new study.

Lauren J. Bains, MD, and colleagues at the University of Bern in Switzerland
prospectively studied 111 men with prostate and/or bladder cancer who
underwent DW-MRI of the pelvis without anendorectal coi prior to radical
prostatectomy (78 patients) or cystoprostatectomy (33 patients). based on
qualitative imaging analysis, 3 independent readers blinded to clinical and
pathologic data assigned a prostate cancer (PCa) suspicion grade. 

The final pathology served as the reference standard. "For study purposes
only the largest tumor focus of the prostate (index lesion) was considered
since it is postulated by some investigators to dictate PCa prognosis," the
researchers noted.

Of the 111 men, 93 had PCa, which was significant in 80 cases and
insignificant in 13, the investigators reported in The Journal of Urology
(2014;192:737-742). The researchers defined significant PCa as any tumor
with a 1 cm or greater diameter, extraprostatic extension, or a Gleason
score of 7 or greater. The sensitivity and specificity of DW-MRI for
detecting significant PCa was 89%-91% and 77%-81%, respectively, for the 3
readers. The median reading time was 13-18 minutes, with good interreader
agreement.

"With all of these advantages DW-MRI has the potential to rapidly
disseminate into clinical practice for PCa management," the authors
concluded.

It may improve patient stratification for individualized treatment options,
such as by discriminating tumors requiring curative treatment from those
that may benefit from expectant management, Dr. Bain's group noted.

"To our knowledge no other study has focused on detecting significant
disease based on final pathology results of entire prostates with and
without preoperatively known PCa," the authors wrote. "This design decreases
the risk of reading bias common to previous studies, in which readers were
aware that the study population consisted of only patients with proven PCa."

 

 

 

url:http://www.renalandurologynews.com/mri-highly-accurate-in-detecting-sign
ificant-prostate-cancer/article/366219/?DCMP=EMC-RENALUROLOGY_TODAYSUPDATE
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cant-prostate-cancer/article/366219/?DCMP=EMC-RENALUROLOGY_TODAYSUPDATE&CPN=
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