[Hopespringpcsg] FW: [PPML] AS - Surveilling Middle-Risk Prostate Cancer: Cautionary Data

[Glen Tolhurst]

Hi all:
See below link to a Canadian article on Active Surveillance by docs at Sunnybrook /Odette in T.O.
Thx.
Glen


Subject: Re: [PPML] AS - Surveilling Middle-Risk Prostate Cancer: Cautionary Data

This is one of an increasing number of studies indicating that Gleason pattern 4 tissues are significantly different than pattern 3 in the risk of cancer progression. Hence the current consensus that a Gleason
6 (3+3) tumor has virtually no risk of progression compared to a Gleason 7 (3+4), and, a Gleason 7 (4+3) presents a significantly higher risk that Gleason 7 (3+4).  The challenge, of course, is obtaining an accurate biopsy (both accurate sampling AND accurate
pathology) for staging.

>
> Source:
> http://www.jurology.com/article/S0022-5347%2816%2931142-9/fulltext
>
> "Conclusions
>
> These data support the use of active surveillance in low risk and 
> intermediate risk cases of Gleason 6 but not Gleason 7 prostate cancer.
> Multiparametric magnetic resonance imaging and novel biomarkers might 
> be vital in detecting favorable Gleason 7 disease."
>