[Hopespringpcsg] FW: What's New in PC for June

[Glen Tolhurst]

Hi all:

See below for a number of articles that were passed to  me by one of the
Chairs of another PCCN group.

Take care,

Glen

 

.

 

Trillium Drug Program: during our May meeting on access to drugs, the
Trillium Program came up. For those, like me, who didn't know about it, here
is a quick introduction. 
https://www.hmabenefits.ca/blog/drugs-dental-what-does-the-trillium-drug-pla
n-cover-your-blog-post-title-here

 

Active Surveillance: we all know that men don't like to go to the doctor but
it becomes a bit ridiculous when they won't even keep up their monitoring
program after opting for Active Surveillance. "Just 15 percent  of a group
of men in North Carolina with early-stage prostate cancer who  chose active
surveillance instead of treatment followed the  recommended monitoring
guidelines".

https://www.eurekalert.org/pub_releases/2019-05/ulcc-mwc053119.php

 

Drug Combinations: if Xtandi (enzalutamide) works one way and Zytiga
(abiraterone) works another way to combat metastatic PC, then a combination
of the two must be even better - right? Unfortunately, that doesn't seem to
be the case (not that many people could afford that duo anyway.) "Overall,
the study shows that more is not better in first-line metastatic therapy"
https://www.medpagetoday.com/meetingcoverage/asco/80187?xid=nl_mpt_DHE_2019-
06-03
<https://www.medpagetoday.com/meetingcoverage/asco/80187?xid=nl_mpt_DHE_2019
-06-03&eun=g675885d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Dail
y%20Headlines%202019-06-03&utm_term=NL_Daily_DHE_Activealter>
&eun=g675885d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20He
adlines%202019-06-03&utm_term=NL_Daily_DHE_Activealter

 

Prostate Cancer Consists of Multiple Tumours: "Most primary prostate cancers
consist of multiple tumors within the same organ, but little is known about
their relationships. We have compared the sets of gene mutations among such
tumors and found that they only exceptionally have any in common".
https://www.ncbi.nlm.nih.gov/pubmed/30181068

This, of course, is why some doctors prefer to treat the whole organ rather
than try 'focal therapy' on the prostate.

 

Focal Therapy: however, the above does not mean that focal therapy might not
be right for some men. Here is another approach "Researchers have shown that
selectively destroying cancerous prostate tissue is as effective as complete
prostate removal"

https://www.sciencedaily.com/releases/2019/03/190320132051.htm

 

ADT Side Effects; most men have some degree of side effects from ADT and are
told that they should exercise more.

Here is the abstract of a study that concludes that "diet and physical
activity intervention can minimize the adverse body composition changes
associated with ADT" https://www.ncbi.nlm.nih.gov/pubmed/25916660

 

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