[CTN] CTN Seminar: Alexander Mathis, Tuesday May 23, 3:30 in PAS 2464

[Bryan Tripp]

Hi everyone,

Just a reminder about the talk today at 3:30.

Bryan


On Mon, May 15, 2017 at 10:44 AM, Bryan Tripp <bptripp at gmail.com> wrote:

> Hi everyone,
>
> I'm forwarding this message on behalf of Travis DeWolf ...
>
> Special invited speaker session with Alexander Mathis, next Tuesday (May
> 23rd) at 3:30 in the PAS room 2464, discussing the work presented recently
> in Neuron (http://www.cell.com/neuron/pdf/S0896-6273(17)30157-5.pdf
> <https://connect.uwaterloo.ca/owa/redir.aspx?C=PV4tOG5twQjngrMGkyuB_C1WsVGZZ016ClP3WZ6BonHQah9PoJvUCA..&URL=http%3a%2f%2fwww.cell.com%2fneuron%2fpdf%2fS0896-6273(17)30157-5.pdf>
> )
>
>
> Title: Somatosensory Cortex Plays an Essential Role in Forelimb Motor
> Adaptation in Mice
>
> Abstract: Motor adaptation is fundamental for agile motor control in
> changing environments, such as perturbations of the body or tools we
> interact with. Motor adaptation is thought to depend on the ability to form
> a memory of a systematic perturbation, often called an internal model.
> However, the mechanisms underlying the formation, storage, and expression
> of such models remain unknown. I will present a mouse model, that we
> recently developed, to study forelimb adaptation to force field
> perturbations. We found that temporally precise photoinhibition of
> somatosensory cortex (S1) applied concurrently with the force field
> abolished the ability to update subsequent motor commands needed to reduce
> motor errors. This S1 photoinhibition did not impair basic motor patterns,
> post-perturbation completion of the action, or their performance in a
> reward-based learning task. Moreover, S1 photoinhibition after partial
> adaptation blocked further adaptation, but did not affect the expression of
> already-adapted motor commands. Thus, S1 is critically involved in updating
> the memory about the perturbation that is essential for forelimb motor
> adaptation.
>
>
> If you would like to attend lunch with Alexander, please contact
> tdewolf at uwaterloo.ca
> <https://connect.uwaterloo.ca/owa/redir.aspx?C=aucf-zHC3a0V4EHoflRwTO8VMRhV-N4-G1-v6GtjQcvQah9PoJvUCA..&URL=mailto%3atdewolf%40uwaterloo.ca>
> See you then!
>
>
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