[Hopespringpcsg] FW: FYI From urotoday.com Topic: Impact of family history on prostate cancer mortality in Caucasian men undergoing PSA-based screening

[Glen Tolhurst]

Hi all:

Interesting article that reinforces the need to consider family history as
it relates to Prostate Cancer.

Ensure family members of those diagnosed with PCa get a PSA test.

Thx.

Glen

 


Subject: FYI From urotoday.com Topic: Impact of family history on prostate
cancer mortality in Caucasian men undergoing PSA-based screening

 


Impact of family history on prostate cancer mortality in Caucasian men
undergoing PSA-based screening - Abstract
<http://www.urotoday.com/Prostate-Cancer/impact-of-family-history-on-prostat
e-cancer-mortality-in-caucasian-men-undergoing-psa-based-screening-abstract.
html>  


Published on 04 September 2014

PURPOSE: To assess if prostate cancer (PCa) screening reduces PCa mortality
in Caucasian men with a family history (FH) of prostate cancer.

MATERIALS AND METHODS: Data from the Prostate, Lung, Colorectal, and Ovarian
(PLCO) screening trial was used to compare screening and usual care arms
within the subset of men with and without a FH of PCa. Univariate,
multivariate cox regression analysis, and log-rank analysis of Kaplan-Meier
curves were used to examine the data for differences in PCa specific
survival.

RESULTS: A total of 65,179 Caucasian subjects were included in the PSA
screening trial, of which 7314 (11.2%) were diagnosed with PCa. Only 4,833
(7.4%) of Caucasian men had a FH of PCa. FH+ men had a significantly higher
PCa incidence (16.9% vs. 10.8%; p< 0.01) and higher PCa specific mortality
(0.56% vs. 0.37%; P< 0.01), which trended to significance in multivariate
analysis (HR 1.47, 95% CI: 0.98-2.21; p=0.06). Screening FH+ men also showed
a trend towards decreased PCa specific mortality with a hazard ratio of 0.49
(95% CI 0.22-1.1; p=0.08) and also a reduced time to death from PCa
(log-rank; p=0.05).

CONCLUSIONS: Caucasian men with a FH of PCa are at increased risk of being
diagnosed and subsequently dying from prostate cancer. Yearly digital rectal
exams and PSA testing may reduce prostate cancer death in these individuals.

Written by: 
Liss MA, Chen H, Hemal S, Krane S, Kane CJ, Xu J, Kader AK.
<http://www.urotoday.com/index.php?option=com_content&Itemid=797&catid=1168&
id=18027&lang=en&view=article>   Are you the author? 
UC San Diego Health System, Department of Urology, San Diego, CA; State Key
Laboratory of Genetic Engineering, School of Life Sciences, Fudan
University, Shanghai, China; Wake Forest University School of Medicine,
Departments of Genomics and Personalized Medicine Research, Winston-Salem,
NC; Department of Urology Wake Forest University School of Medicine; UC San
Diego Health System, Department of Urology, San Diego, CA.
mliss008 at gmail.com



url:http://www.urotoday.com/Prostate-Cancer/impact-of-family-history-on-pros
tate-cancer-mortality-in-caucasian-men-undergoing-psa-based-screening-abstra
ct.html

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